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Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels

June 2024

Stiffness gradients in alginate gels can guide cancer cell invasion and study cellular behaviors.

research Signaling modality within gp130 receptor enhances tissue regeneration

January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The gp130 receptor helps in tissue regeneration and disease progression, and manipulating it could improve healing and prevent disease.

research Trichothiodystrophy

1 citations , January 2008

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Two-dimensional electrophoretic analysis of human hair keratins, especially hair matrix proteins

10 citations , January 1989 in “Archives of Dermatological Research”

The method effectively analyzes human hair proteins, especially nonfilamentous ones.

research Uso de la simulación en el control de errores en la Rasterización

2 citations , January 1997 in “Mapping”

Gambogic Amide may prevent hair greying and promote hair growth by maintaining hair pigmentation.

research Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice

11 citations , January 2015 in “Journal of cellular physiology”

HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

research Compound glycyrrhizin promotes hair growth in C57BL/6 mice by regulating the Wnt/β-catenin pathway

July 2025 in “Dermatologica Sinica”

Glycyrrhizin may help regrow hair by activating a specific pathway.

research LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem‐Like Cells

82 citations , July 2012 in “Brain pathology”

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

39 citations , March 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

GLI2 increases follistatin production in human skin cells.

research [Analysis of normal human hair keratins by two-dimensional polyacrylamide gel electrophoresis].

May 1988 in “PubMed”

research Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

23 citations , March 2023 in “eLife”

Stem cell differentiation involves gradual chromatin changes and dynamic gene activity.

research An Autosomal Recessive Form of Monilethrix Is Caused by Mutations in DSG4: Clinical Overlap with Localized Autosomal Recessive Hypotrichosis

97 citations , March 2006 in “Journal of Investigative Dermatology”

Mutations in the DSG4 gene cause a severe form of brittle hair and skin issues.

research Senile hair graying: H ₂ O ₂ ‐mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

217 citations , February 2009 in “The FASEB Journal”

Gray hair is caused by hydrogen peroxide buildup, which damages hair color repair.

research THE GRADE OF HIRSUTISM CORRELATED TO SERUM ANDROGEN LEVELS AND HORMONAL INDICES

18 citations , January 1985 in “Acta Obstetricia Et Gynecologica Scandinavica”

Hirsutism severity is linked to androgen levels, especially in women with a lower LH/FSH ratio.

research Faculty Opinions recommendation of Modulation of phospholipid signaling by GLABRA2 in root-hair pattern formation.

September 2003 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

GLABRA2 gene controls root-hair growth by regulating phospholipid signaling.

research 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors

January 2004

The document's conclusion cannot be provided because the document is not available or cannot be read.

Morphogenesis and Hair Cycle-Dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III, and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles

research Morphogenesis- and Hair Cycle-dependent Expression of Trichohyalin, Peptidylarginine Deiminase Type III and Deiminated Trichohyalin in Rat Dorsal Skin Hair Follicles

January 2001 in “Biomedical Research”

THH and PAD type III appear together early in hair growth, but deiminated THH appears later, suggesting another factor is involved.

research Issue Information

May 2021 in “FEBS open bio”

research The Agouti Gene in Obesity: Central and Peripheral Mechanisms, and Therapeutic Implications

May 2001

The agouti gene may help understand and treat obesity.

Androgen Receptor Gene Polymorphism (SNP RS6152) – Its Relationship to Androgen-Sensitive Genes Expression in Benign Prostatic Hyperplasia, Carcinoma of the Prostate, and Androgenetic Alopecia

research 409 ANDROGEN RECEPTOR GENE POLYMORPHISM (SNP RS6152) – ITS RELATIONSHIP TO ANDROGEN-SENSITIVE GENES EXPRESSION IN BENIGN PROSTATIC HYPERPLASIA, CARCINOMA OF THE PROSTATE AND ANDROGENETIC ALOPECIA

March 2011 in “European Urology Supplements”

Gene variation affects prostate issues and hair loss.

research Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene

26 citations , September 2010 in “Experimental Dermatology”

Two gene areas linked to male pattern baldness found, more research needed.

research Proteoglycans and Associated Proteins of the Mammalian Hair Follicle

7 citations , May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology”

research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

3 citations , January 2024 in “Frontiers in Endocrinology”

Androgens can affect glucocorticoid signaling in specific mouse brain areas.

research The Molecular Architecture for the Intermediate Filaments of Hardα-Keratin Based on the Superlattice Data Obtained from a Study of Mammals Using Synchrotron Fibre Diffraction

7 citations , January 2011 in “Biochemistry Research International”

Hard α-keratin has a universal molecular structure with a specific superlattice arrangement.

research GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis

24 citations , December 2013 in “Archives of Dermatological Research”

research Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

15 citations , May 2014 in “Journal of Biological Chemistry”

A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.

research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice

2 citations , June 2023 in “Journal of cell science”

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

research Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation

1 citations , January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

Increased PHGDH expression causes early melanin buildup in hair follicles.

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