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Did you mean Growth Differentiation Factor 8?

GlossaryGrowth Differentiation Factor 8

inhibits muscle growth by signaling muscles to stop growing

Growth Differentiation Factor 8 (GDF-8), also known as Myostatin, is a protein that inhibits muscle growth. It plays a crucial role in regulating muscle mass by signaling muscles to stop growing, ensuring that muscle growth does not become excessive. This protein is of particular interest in medical research for its potential implications in treating muscle-wasting diseases and enhancing muscle growth in livestock.

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Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

10 citations , May 2016 in “Journal of Dermatological Science”

PDGF-BB helps young melanocytes grow but stops mature ones from growing, and it makes melanocytes more specialized.

Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration

5 citations , September 2019 in “ACS Applied Bio Materials”

The hydrogel with bioactive factors improves skin healing and regeneration.

research Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin

90 citations , August 2004 in “Physiological Genomics”

Dermal papilla cells help skin stem cells grow into hair.

research Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors

73 citations , November 2001 in “Journal of Investigative Dermatology Symposium Proceedings”

Markers help differentiate between apocrine and eccrine sweat glands to identify sweat gland tumors.

research AB0163 ANTI-KU ANTIBODIES: MUCH MORE THAN SCLEROMYOSITIS

June 2020 in “Annals of the Rheumatic Diseases”

Patients with Systemic Sclerosis have much higher levels of GDF-15, which could help predict organ involvement and guide treatment.

research Role of insulin resistance and diet in acne

39 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

research Distinct tooth regeneration systems deploy a conserved battery of genes

September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Different fish use the same genes to regrow teeth.

research 516 Intrinsic factors regulating hair growth: insights into growth factors, cytokines, chemokines, and interferons

November 2024 in “Journal of Investigative Dermatology”

Red ginseng components help prevent skin aging by reducing inflammation and improving cell function.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

Co-Expression Pattern of VEGFR-2 With Indicators Related to Proliferation, Apoptosis, and Differentiation of Anagen Hair Follicles

research The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles

January 2023 in “Open Life Sciences”

VEGFR-2 activation is likely involved in hair follicle growth, survival, and development.

research Human basal cell carcinoma: the induction of anagen hair follicle differentiation

3 citations , September 2019 in “Clinical and experimental dermatology”

Basal cell carcinomas may differentiate similarly to hair follicles and could be influenced by hair cycle-related treatments.

research Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

130 citations , March 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.

research A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective

8 citations , July 2022 in “International Journal of Molecular Sciences”

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.

research Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

25 citations , September 2018 in “Molecular Biology of the Cell”

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

research Adipose stem cells isolated from diabetic mice improve cutaneous wound healing in streptozotocin-induced diabetic mice

29 citations , March 2020 in “Stem Cell Research & Therapy”

Fat stem cells from diabetic mice can help heal skin wounds in other diabetic mice.

research Cutaneous Side Effects in Non-Small Cell Lung Cancer Patients Treated with Iressa (ZD1839), an Inhibitor of Epidermal Growth Factor

116 citations , December 2003 in “Acta Dermato Venereologica”

Iressa often causes skin issues like acne and dryness in lung cancer patients.

research The hair cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions

56 citations , March 2015 in “Journal of Investigative Dermatology”

Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.

KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

research KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin

82 citations , May 2009 in “Development”

EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.

research The Developmental & Molecular Requirements for Ensuring that Human Pluripotent Stem Cell-Derived Hair Follicle Bulge Stem Cells Have Acquired Competence for Hair Follicle Generation Following Transplantation

4 citations , January 2021 in “Cell transplantation”

Scientists found the best time to transplant human stem cells for hair growth is between days 16-18 when they have the right markers and growth potential.

research Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839

1 citations , March 2004 in “Journal of the American Academy of Dermatology”

ZD1839, a cancer drug, can cause mild skin rashes that are treatable without stopping the medication.

research Retinoic Acid-Induced Epidermal Transdifferentiation in Skin

1 citations , June 2014 in “Journal of developmental biology”

Retinoic acid helps change skin cells and is important for skin development and hair growth.

research Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion

1 citations , July 2025 in “Journal of Human Immunity”

Minoxidil helps restore thymus size in 22q11.2 deletion syndrome.

research Suppression of Vitamin D Receptor and Induction of Retinoid X Receptor α Expression During Squamous Differentiation of Cultured Keratinocytes

15 citations , March 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.

Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Isoproterenol directs hair follicle-associated pluripotent (HAP) stem cells to differentiate in vitro to cardiac muscle cells which can be induced to form beating heart-muscle tissue sheets

29 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.

research A perspective on predictive markers of alopecia

January 2020 in “Archives of Medicine and Health Sciences”

Certain immune molecules and stress affect hair loss, and while genes play a role, more research is needed to fully understand and treat it.

research Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

10 citations , January 2020 in “Acta Neurobiologiae Experimentalis”

Valproic acid and crocin together boost cell growth and may help treat nerve injuries.

research Keratinocyte Stem Cells but Not Melanocyte Stem Cells Are the Primary Target for Radiation-Induced Hair Graying

30 citations , April 2013 in “Journal of Investigative Dermatology”

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

Dermal Fibroblasts Enhance Growth Factors Production by Androgens and Modulate Keratinocyte Proliferation and Differentiation

research 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Androgens increase growth factors in skin cells, which may lead to acne.