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Analysis of Hidradenitis Suppurativa-Linked Mutations in Four Genes and the Effects of PSEN1-P242LfsX11 on Cytokine and Chemokine Expression in Macrophages

research Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages

25 citations , December 2018 in “Human Molecular Genetics”

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

research 898 Homeostatic activation of epidermal HSD11b1 affects skin innervation and non-histaminergic itch

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

HSD11b1 affects skin nerves and increases non-histaminergic itch.

Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial

research Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial

20 citations , January 2013 in “Evidence-based complementary and alternative medicine”

TGPC plus CGT is effective and safe for treating severe alopecia areata in children.

research 41701 Efficacy of the Oral JAK1/JAK2 Inhibitor CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata: Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 Phase 3 Trial

2 citations , September 2023 in “Journal of the American Academy of Dermatology”

CTP-543 effectively promotes hair regrowth in adults with moderate to severe alopecia areata.

research TGF-α Is Widely Expressed in Differentiated as well as Hyperproliferative Skin Epithelium

56 citations , March 1991 in “Journal of Investigative Dermatology”

research Generalized trichorrhexis nodosa

28 citations , July 1980 in “British Journal of Dermatology”

The hair disorder was caused by abnormal protein formation, making hair easily damaged.

research Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis

12 citations , May 2023 in “Molecules”

Polygoni Cuspidati Rhizoma et Radix contains compounds that inhibit certain enzymes.

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

research A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms

21 citations , January 1995 in “Molecular Biology Reports”

Scientists discovered two versions of a new human hair keratin gene.

research Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice

2 citations , June 2024 in “Parasites & Vectors”

Chronic T. gondii infection may harm male fertility.

research Preparation of finasteride by selective dehydrogenation using IBX

January 2009 in “Chemical Reagents”

The method produces finasteride with a 92% yield.

Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Identification of Potential Key Genes and Pathways Associated with the Pashmina Fiber Initiation Using RNA-Seq and Integrated Bioinformatics Analysis

research Identification of potential key genes and pathways associated with the Pashmina fiber initiation using RNA-Seq and integrated bioinformatics analysis

36 citations , January 2021 in “Scientific Reports”

Key genes and pathways, including Wnt, NF-Kappa, and JAK-STAT, are crucial for starting Pashmina fiber growth in goats.

research GSK-3 Inhibitors: Recent Developments and Therapeutic Potential

3 citations , September 2008 in “Current signal transduction therapy”

Drugs that block GSK-3 show promise for treating various diseases.

research Depletion of Gsdma1/2/3i> alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway

6 citations , December 2023 in “Journal of Molecular Cell Biology”

Removing Gsdma1/2/3 genes reduces skin cell overgrowth by blocking a specific cell pathway.

research 17beta Hydroxysteroid Dehydrogenase Type 3 Inhibitors
January 2004

The document's conclusion cannot be provided because the document is not available or cannot be read.

research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats
13 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Mutations in the DSG4 gene cause fragile, sparse hair in humans, mice, and rats.

research Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2
8 citations , January 2012 in “JIMD reports”

A new mutation in the AGPAT2 gene causes severe fat tissue loss and related health issues by reducing the protein's levels.

research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome
119 citations , November 2016 in “American journal of human genetics”

Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.

research 197 A novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair
August 2016 in “Journal of Investigative Dermatology”

Researchers found a new genetic mutation linked to a hair condition in a Japanese boy.

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse
6 citations , August 2014 in “Toxicologic pathology”

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

research 088 β-catenin stimulating peptide stimulates the hair growth through the DKK-1 signaling modulation
July 2024 in “Journal of Investigative Dermatology”

A peptide in shampoo can promote hair growth and improve hair condition.

research Biotinidase Deficiency: Prevalence, Impact And Management Strategies.
89 citations , January 2020 in “PubMed”

Early detection and biotin treatment improve outcomes for biotinidase deficiency.

research Isolation and Characterization of a Novel Hair Follicle–Specific Gene, Hacl-1
25 citations , May 1994 in “Journal of Investigative Dermatology”

Researchers found a new gene, hacl-1, that is active in mouse hair follicles during hair growth and may be important for hair biology.

research 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes
43 citations , August 2010 in “Expert Opinion on Investigational Drugs”

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

research Etude des multiples rôles des phosphatidylinositol-4-kinases betas dans la morphogenèse et les réponses de défense d'Arabidopsis thaliana
November 2022 in “Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)”

Phosphatidylinositol 4-kinases are crucial for root growth, defense, and immunity in Arabidopsis thaliana.

research The Analysis of the Expression of TGF-beta in Human Hair Follicles in vivo
April 2007 in “Linchuang pifuke zazhi”

TGF-β1 and 2 may play a role in hair loss in AGA.

research Re: Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement
November 2012 in “The Journal of Urology”

Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.

research Intracrine Testosterone Activation in Human Pancreatic β-Cells Stimulates Insulin Secretion
11 citations , August 2020 in “Diabetes”

Testosterone helps human pancreatic cells increase insulin release.

research Expression of Calcyclin, a Calcium-Binding Protein, in the Keratogenous Region of Growing Hair Follicles
40 citations , March 1991 in “Journal of Investigative Dermatology”

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