Search

for
Search:

Did you mean Bulge Region?

GlossaryBulge Region

specific area in hair follicle housing stem cells

The bulge region is a specific area located in the outer root sheath of a hair follicle. It contains a reservoir of stem cells that are crucial for hair growth and regeneration. These stem cells can also contribute to the repair of the skin and other tissues, making the bulge region essential for both hair health and overall skin maintenance.

Related Terms

Sort by

Research

30 / 1000+ results

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Autofluorescence in the Stem Cell Region of the Hair Follicle Bulge

17 citations , March 2005 in “Journal of Investigative Dermatology”

Autofluorescence in hair follicle stem cells can interfere with studies but may help isolate these cells.

research 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion

September 2019 in “Journal of Investigative Dermatology”

IL-17 and certain immune cells are linked to more severe alopecia areata.

research Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

107 citations , May 1999 in “Archives of Dermatological Research”

Basal cell carcinoma may start from parts of tiny hair follicles.

Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata

research Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata

20 citations , December 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Decreased CD200 in hair follicles may cause immune issues in some alopecia areata cases.

$Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation$

research Human keratinocytes derived from the bulge region of hair follicles are refractory to differentiation

8 citations , April 2009 in “International journal of oncology”

Hair follicle cells resist turning into skin cells.

research In vitro identification of a stem cell population from canine hair follicle bulge region

5 citations , December 2017 in “Tissue and cell/Tissue & cell”

Researchers found stem cells in dog hair follicles using specific markers.

research Abstract 4300: Constitutive activation of Stat3 increases hair follicle progenitor population at the expense of bulge region keratinocyte stem cells

April 2010 in “Cancer Research”

Stat3 activation increases hair follicle progenitors but reduces bulge region stem cells.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region

5 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Proteolytic enzymes damage hair follicles by detaching stem cells.

research The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region

2 citations , July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Proteolytic enzymes damaged hair follicle stem cells in transgenic mice.

research Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human

1 citations , January 2020 in “Microscopy research”

Researchers successfully grew hair follicle stem cells from mice and humans, which could be useful for tissue engineering and regenerative medicine.

Immune Response Involving the Bulge Region in Addition to Telogen Conversion Contributes to Hair Loss in a Case of Atypical Drug-Induced Hypersensitivity Syndrome

research Immune response involving the bulge region in addition to telogen conversion contributes to hair loss in a case of atypical drug-induced hypersensitivity syndrome

1 citations , October 2013 in “The Journal of Dermatology”

Hair loss in a drug reaction case involved both a common shedding phase and an immune attack on hair follicle stem cells.

research The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice

9 citations , June 1999 in “Journal of Investigative Dermatology”

The HPV type 11 region activates hair-specific gene expression in mice.

Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells

research Advances in the Study of Stem-Cell-Enriched Hair Follicle Bulge Cells: A Review Featuring Characterization and Isolation of Human Bulge Cells

16 citations , January 2007 in “Dermatology”

Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.

research TR3 is preferentially expressed by bulge epithelial stem cells in human hair follicles

7 citations , January 2016 in “Laboratory Investigation”

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

research The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles

5 citations , November 2015 in “International Journal of Radiation Biology”

Gamma-ray exposure can cause long-lasting damage to hair follicles, affecting hair structure and color.

research Effects of gamma rays on the regeneration of murine hair follicles in the natural hair cycle

3 citations , June 2017 in “International Journal of Radiation Biology”

Gamma rays did not change hair follicle density but increased white and hypopigmented hairs in mice.

Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

research Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2

21 citations , November 2017 in “Scientific Reports”

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

research Histology and ultrastructure of canine hair follicle stem cells (cHFSCs)

January 2020 in “Journal of Entomology and Zoology Studies”

Canine hair follicle stem cells are located in the isthmus/bulge region of the hair follicle.

research Hair Biology and Androgenetic Alopecia

June 2018 in “Advances in Cosmetic Surgery”

Hair loss caused by genetics and hormones; more research needed for treatments.

research 503 A new chemosensory control of human hair growth: Olfactory receptor OR10J1 stimulation promotes scalp hair follicle growth and progenitor cell generation ex vivo

November 2024 in “Journal of Investigative Dermatology”

Stimulating OR10J1 can promote hair growth and may help treat hair loss.