September 2023 in “Frontiers in medicine” The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
224 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
62 citations
,
December 2013 in “Aaps Journal” Squarticles effectively deliver hair growth drugs to follicles and dermal papilla cells.
25 citations
,
July 2019 in “Experimental Dermatology” Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.
16 citations
,
November 2020 in “International journal of pharmaceutics” Using longer PEG chains helps nanoparticles penetrate hair follicles better, improving drug delivery for conditions like alopecia.
13 citations
,
February 2018 in “Bio-medical Materials and Engineering” Minoxidil inside tiny particles can deliver more drug to hair follicles, potentially improving treatment for hair loss.
12 citations
,
May 2019 in “Stem cell reviews” Fetal-maternal stem cells in a mother's hair can help with tissue repair and regeneration long after childbirth.
September 2016 in “Journal of Dermatological Science” Certain factors can start hair growth in adult skin by making cells communicate and form new hair follicles.
19 citations
,
March 1996 in “British Journal of Dermatology” Balding hair follicle cells are smaller, grow less well, and need more effort to culture than non-balding cells.
95 citations
,
January 2012 in “British Journal of Dermatology” Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
50 citations
,
May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.
37 citations
,
October 2009 in “Dermatology” Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.
30 citations
,
December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.
26 citations
,
May 2019 in “PLOS ONE” Hair loss patients have different microbes in hair follicles, possibly affecting hair loss.
25 citations
,
March 2014 in “Experimental Dermatology” Leptin helps start the growth phase of hair.
6 citations
,
March 2016 in “British Journal of Dermatology” Low IGF-1 and high HDL cholesterol levels are linked to more hair loss in middle-aged women.
4 citations
,
May 2019 in “Skin Research and Technology” Finasteride helps hair growth but stopping it causes faster hair loss.
2 citations
,
March 2021 in “Molecular Immunology” Dermal macrophages might help regrow hair.
1 citations
,
April 2021 in “Journal of Investigative Dermatology” Activating TRPA1 reduces scarring and promotes tissue regeneration.
April 2024 in “Frontiers in physiology” Immune cells are crucial for hair growth and preventing hair loss.
8 citations
,
February 2017 in “Archives of Dermatological Research” Intense pulsed light treatment effectively reduces underarm hair by making hair follicles smaller and extending their resting phase.
4 citations
,
December 2020 in “International journal of research - granthaalayah” Tetracycline can stick to hair follicles and potentially cause hair loss.
316 citations
,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
192 citations
,
March 2017 in “Cell host & microbe” Hair follicle development and microbes help regulatory T cells gather in newborn skin.
113 citations
,
November 2017 in “Scientific Reports” Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
98 citations
,
July 2014 in “Trends in Molecular Medicine” Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.
94 citations
,
September 2014 in “Therapeutic Delivery” Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.
65 citations
,
November 2012 in “Tissue Engineering Part B-reviews” Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.
60 citations
,
February 1997 in “Journal of Dermatological Science” Liposomes can safely and effectively deliver substances to mouse hair follicles, potentially useful for human hair treatments.
48 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” Hair follicles offer promising targets for delivering drugs to treat hair and skin conditions.