170 citations
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July 2012 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
149 citations
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July 2014 in “Cold Spring Harbor Perspectives in Medicine” The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.
136 citations
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May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
127 citations
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March 2016 in “PLoS ONE” Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.
124 citations
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August 1994 in “Journal of Investigative Dermatology” Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.
100 citations
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November 1996 in “Molecular Medicine Today” Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.
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July 2014 in “Trends in Molecular Medicine” Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.
98 citations
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February 2007 in “Seminars in Cell & Developmental Biology” Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.
87 citations
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April 2018 in “Biochemical and Biophysical Research Communications” Exosomes from dermal papilla cells can help grow hair and might treat hair loss.
86 citations
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December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
77 citations
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March 2021 in “Nature” Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.
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January 2015 in “International Journal of Biological Macromolecules” Chitosan nanoparticles improve minoxidil delivery to hair follicles for better alopecia treatment.
75 citations
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October 2016 in “Genes & Development” Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
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June 2001 in “Journal of Investigative Dermatology” S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
68 citations
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August 2014 in “Stem Cells Translational Medicine” Dermal papilla cells help wounds heal better and can potentially grow new hair.
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March 2018 in “British journal of dermatology/British journal of dermatology, Supplement” An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.
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September 2004 in “The American journal of pathology” Blocking BMP signaling causes hair loss and disrupts hair growth cycles.
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March 2020 in “Journal of Biomedical Science” Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
58 citations
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March 2019 in “Experimental Dermatology” Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
52 citations
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May 2015 in “PLOS Genetics” miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.
45 citations
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November 2017 in “Biomaterials” Researchers found a new way to create hair-growing structures in the lab that can grow hair when put into mice.
44 citations
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September 2019 in “The EMBO Journal” Lymphatic vessels are essential for hair follicle growth and skin regeneration.
42 citations
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February 2017 in “Scientific Reports” Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.
38 citations
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June 2017 in “The Journal of Dermatology” Aging in hair follicle stem cells leads to hair graying, thinning, and loss.
35 citations
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July 2018 in “Cell Reports” The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.
35 citations
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January 2014 in “Journal of Tissue Engineering” Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.
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June 2008 in “In vitro cellular & developmental biology. Animal” Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.
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August 2019 in “Nature Communications” Chemotherapy causes permanent hair follicle damage by triggering stem cell loss.
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October 2016 in “PLoS ONE” The ubiquitin-mediated proteolysis pathway is crucial for hair follicle development in cashmere goats.
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April 2017 in “Experimental Dermatology” Hair follicle stem cells and skin cells show promise for hair and skin therapies but need more research for clinical use.