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GlossaryHair Follicle Stem Cells

specialized cells in hair follicles that regenerate hair and skin

Hair Follicle Stem Cells (HFSCs) are specialized cells located in the bulge region of hair follicles. They play a crucial role in the growth and regeneration of hair by periodically activating to produce new hair shafts and contribute to the repair of skin injuries. These cells have the unique ability to self-renew and differentiate into various cell types, making them essential for maintaining healthy hair and skin.

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A Review: The Location, Molecular Characterization and Multipotency of Hair Follicle Epidermal Stem Cells

research A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells

61 citations , November 2004 in “Annals of the Academy of Medicine Singapore”

Hair follicle stem cells are mainly in the bulge region and can help repair skin and form hair and glands, but more research is needed to fully understand them.

research In vitro culture of murine fetal epidermal stem cell and its relationship with the regeneration of hair follicle

January 2003 in “Zhonghua shaoshang zazhi”

Murine fetal epidermal stem cells can help regenerate hair follicles.

research Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis

1 citations , July 2025 in “JCI Insight”

Hair follicle stem cells help maintain skin health by moving to and supporting the skin's surface layers.

research MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5

1 citations , September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

MicroRNA-148a is crucial for maintaining healthy skin and hair growth by affecting stem cell functions.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Exosomes from Hair Follicle Epidermal Neural Crest Stem Cells Promote Acellular Nerve Allografts to Bridge Rat Facial Nerve Defects

December 2022 in “Stem Cells and Development”

Exosomes from stem cells help improve nerve repair in rats.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

research Epidermal stem cells and skin tissue engineering in hair follicle regeneration

83 citations , January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment

14 citations , January 2021 in “Stem cell research & therapy”

Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.

research Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin

23 citations , April 2016 in “Journal of Visualized Experiments”

The method successfully isolates hair follicle stem cells from mice for research.

research Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin

13 citations , April 2016 in “Journal of Visualized Experiments”

The method successfully isolates hair follicle stem cells and skin cells from mice for research.

research The contribution of stem cells to epidermal and hair follicle tumours in the dog

18 citations , January 2013 in “Veterinary Dermatology”

K15 is a reliable marker for studying stem cells in dog hair follicle tumors.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration

47 citations , September 2015 in “Cell Cycle”

Different skin stem cells help heal wounds, with hair follicle cells becoming more important over time.

research 568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation

November 2022 in “Journal of Investigative Dermatology”

Autophagy in skin cells is important for preventing inflammation, skin tumors, and controlling hair growth timing.

research Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis

April 2010 in “Cancer Research”

CDK4 levels affect the number of hair follicle stem cells in mice.

research Decision letter: Hair follicle epidermal stem cells define a niche for tactile sensation

August 2018

Hair follicle stem cells are crucial for touch sensation and proper nerve structure in mice.

Application of Second Near Infrared Fluorescence Imaging to Trace CelTrac1000-Labeled Hair Follicle Epidermal Neural Crest Stem Cells in Repairing Rat Facial Nerve Defects

research Application of second near infrared fluorescence imaging to trace CelTrac1000-labeled hair follicle epidermal neural crest stem cells in repairing rat facial nerve defects

November 2023 in “Research Square (Research Square)”

NIR-II imaging effectively tracked stem cells that helped repair facial nerve defects in rats.

research Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

44 citations , July 2016 in “Stem Cells Translational Medicine”

Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.

research Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts

11 citations , January 2013 in “Methods in molecular biology”

The method allows for 3D tracking of hair follicle stem cells and shows they can regenerate hair for up to 180 days.

research Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures

10 citations , June 2016 in “Cell Transplantation”

Sebaceous glands can help harvest hair follicle stem cells to regenerate skin and hair.

research sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation

9 citations , June 2016 in “Stem cells”

Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.

research Epidermal growth factor promotes mesenchymal stem cell-mediated wound healing and hair follicle regeneration.

4 citations , January 2017 in “PubMed”

Epidermal growth factor helps stem cells heal wounds and regenerate hair follicles faster.

research Hair follicle stem cells promote epidermal regeneration under expanded condition

February 2024 in “Frontiers in physiology”

Hair follicle stem cells help skin heal and grow during stretching.

research 449 Long-Term Role of Hair Follicle Stem Cells in Epidermal Wound Healing

November 2025 in “Journal of Investigative Dermatology”

Hair follicle stem cells help maintain skin health after injury.

research Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation

18 citations , November 2020 in “Frontiers in Cell and Developmental Biology”

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Pre-Aggregation of Scalp Progenitor Dermal and Epidermal Stem Cells Activates the WNT Pathway and Promotes Hair Follicle Formation In Vitro and In Vivo Systems

research Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems

17 citations , December 2019 in “Stem Cell Research & Therapy”

Grouping certain skin cells together activates a growth pathway that helps create new hair follicles.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide

2 citations , November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Author response: Hair follicle epidermal stem cells define a niche for tactile sensation

October 2018

Skin stem cells in hair follicles are important for touch sensation.

research Preliminary studies of hair follicle regeneration by injections of epidermal stem cells and dermal papilla cells into nude mice

5 citations , March 2020 in “Cell and Tissue Banking”

Injected cells show potential for hair growth.