Search

for
Search:

Did you mean Hair Follicle Tumors?

GlossaryHair Follicle Tumors

abnormal growths originating in hair-producing skin structures

Hair follicle tumors are abnormal growths that originate in the hair follicles, the tiny structures in the skin from which hair grows. These tumors can be benign (non-cancerous) or malignant (cancerous) and may present as lumps or lesions on the skin. They can vary in appearance and behavior, requiring different diagnostic and treatment approaches depending on their type and severity.

Related Terms

Sort by

Research

30 / 1000+ results

research Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

335 citations , March 2004 in “Development”

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

research Cylindroma as Tumor of Hair Follicle Origin

57 citations , February 2006 in “Journal of Investigative Dermatology”

Cylindromas likely originate from hair follicle stem cells, not sweat glands.

research Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin?

18 citations , January 2009 in “Experimental Dermatology”

mTOR may link different pathways in hair follicle tumor formation.

research The contribution of stem cells to epidermal and hair follicle tumours in the dog

18 citations , January 2013 in “Veterinary Dermatology”

K15 is a reliable marker for studying stem cells in dog hair follicle tumors.

Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors

research Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors

5 citations , August 2020 in “Curēus”

The document concludes that recent studies help tell apart desmoplastic trichoepitheliomas from other skin tumors, but more research is needed for clear differentiation.

research Keratinic amyloid deposition in canine hair follicle tumors

1 citations , October 2022 in “Veterinary pathology”

Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.

research Hair follicle tumors in dogs: A report of two cases

1 citations , January 2015 in “Indian Journal of Veterinary Pathology”

Two dogs had different types of hair follicle tumors.

Histopathological Characteristics May Not Be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appendages Originating from Hair Follicle

research Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

1 citations , September 2011 in “UHOD : Uluslararası hematoloji - onkoloji dergisi”

Looking at tissue characteristics isn't reliable for telling apart basal cell carcinoma from certain benign skin tumors.

Evaluation of Hair Follicles as a Surrogate Tissue for Pharmacodynamic Response in Xenograft Tumors

research Evaluation of hair follicles as a surrogate tissue for pharmacodynamics response in xenograft tumors

January 2012

Hair follicles can be used to quickly assess drug effects in cancer treatment.

research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

297 citations , January 2002 in “Development”

Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.

research CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice

141 citations , May 2007 in “Cancer Research”

CD34 is crucial for skin tumor development in mice.

research Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma

8 citations , April 2016 in “Experimental Dermatology”

The type of tumor suppressor affects the form of skin cancer from hair follicle stem cells.

research Faculty Opinions recommendation of The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis.

April 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The vitamin D receptor helps control hair growth and may protect against certain skin tumors.

research Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin

76 citations , March 2005 in “Cancer Research”

Doxorubicin can block blood vessels from hair follicles, reducing skin tumor growth.

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

research Skin stem cells and tumor growth : functions of collagen XVIII in hair follicle cycling and skin cancer, and Bmx tyrosine kinase in tumor angiogenesis

3 citations , January 2014

Collagen XVIII and Bmx tyrosine kinase are important for hair growth and skin cancer development.

research Involvement of hair follicles in skin tumorigenesis, skin homeostasis and wound healing

January 2025 in “Medical Research Archives”

Hair follicles are vital for skin health, cancer prevention, and wound healing.

research 568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation

November 2022 in “Journal of Investigative Dermatology”

Autophagy in skin cells is important for preventing inflammation, skin tumors, and controlling hair growth timing.

research Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells

January 2018 in “eScholarship (California Digital Library)”

Hair follicle stem cells may cause squamous cell carcinoma due to a metabolic shift towards glycolysis.

research 17b-Estradiol is Abundant in Skin and Regulates the Hair Follicle Cycle and Mirex Tumor Promotion

January 2002 in “NCSU Libraries Repository (North Carolina State University Libraries)”

17b-Estradiol in skin affects hair growth and tumor promotion.

research CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.

17 citations , January 2010 in “PubMed”

CD10 helps distinguish between basal cell carcinoma and benign hair follicle tumors.

research Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin.

2 citations , January 1989 in “The Nishinihon Journal of Dermatology”

Seborrheic keratosis likely originates from the upper regions of hair follicles.

research Immune Microenvironment of Hair Follicles in Tumor Immunotherapy

February 2026 in “ImmunoTargets and Therapy”

Tumor immunotherapy can cause hair loss by disrupting hair follicle immunity.

research The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

127 citations , January 2008 in “PloS one”

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

research Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation

4 citations , January 2019 in “Journal of cutaneous pathology”

The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.

research Hair follicle stem cells: Their location, role in hair cycle, and involvement in skin tumor formation

85 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

research Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

52 citations , September 2012 in “Oncogene”

Ubiquitomics of CYLD-Deficient Skin Tumors Reveals Dysregulation of Hair Follicle Keratinocyte Processes

research O02 Ubiquitomics of CYLD-deficient skin tumours reveals dysregulation of hair follicle keratinocyte processes

May 2024 in “British journal of dermatology/British journal of dermatology, Supplement”

CYLD deficiency in skin tumors disrupts hair follicle cell processes and protein secretion.

research Differential diagnosis of basal cell carcinoma and benign tumors of cutaneous appendages originating from hair follicles by using CD34.

13 citations , January 2010 in “PubMed”

research Relative Amounts of Keratin 17 Are Higher Than Those of Keratin 16 in Hair-Follicle-Derived Tumors in Comparison with Nonfollicular Epithelial Skin Tumors

31 citations , March 1995 in “Journal of Investigative Dermatology”