research Tuning Wnt Signals for More or Fewer Hairs
Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
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research Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles
The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.
research Improved Poly (D,L‐lactide) nanoparticles‐based formulation for hair follicle targeting
The improved nanoparticles can effectively target hair follicles for drug delivery.
research Primary Cicatricial Alopecias
Early diagnosis and aggressive treatment are key for managing rare scalp disorders that cause permanent hair loss.
research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.AktWT mice
Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.
research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice
The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.
research Alcohol extract from Vernonia anthelmintica willd (L.) seed counteracts stress-induced murine hair follicle growth inhibition
Alcohol extract from Vernonia anthelmintica seeds may help treat stress-related hair loss.
research Defining the hair follicle stem cell (Part I)
Hair follicle stem cells are key for hair growth and skin repair.
research Clinical, trichoscopic, and histopathologic characteristics of patients with alopecia and hypothyroidism: An observational study
Hypothyroidism patients with hair loss typically have thinning hair, smaller hair follicles, and normal hair shedding.
research An extract of Leontopodium alpinum inhibits catagen development ex vivo and increases hair density in vivo
Edelweiss extract can increase hair density and promote hair growth.
research SOX2 in the Skin
SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.
research Open questions in hidradenitis suppurativa research: a hair biologist's perspective
The conclusion suggests that early signs of hidradenitis suppurativa may start in the hair follicle, with genetic and immune factors playing a role, highlighting the need for more research on the hair follicle's immune system.
research Notes from the Editor Emeritus, 2011–2013
Caffeine can stimulate hair growth, but the best dose and frequency for hair loss treatment are still unknown.
research 176 Hair eruption initiates adverse events of EGFR-targeted cancer therapy
EGFR-targeted cancer therapy can cause skin issues starting at hair follicles, leading to inflammation.
research 875 Exploring the role of microRNAs in alopecia areata
Certain microRNAs may protect against hair loss in alopecia areata and could be potential treatment targets.
research Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration
ePUKs could be valuable for regenerative medicine due to their wound healing abilities.
research 751 Thymic stromal lymphopoeitin controls hair growth
Thymic stromal lymphopoietin (TSLP) promotes hair growth by stimulating specific skin cells.
research Lichen planopilaris
Lichen planopilaris is a chronic, scarring hair loss condition with no definitive cure, requiring accurate diagnosis and treatment to manage symptoms.
research Gene expression of type 2 17β hydroxysteroid dehydrogenase in scalp hairs of hirsute women
Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.
research From Surgery to Pharmacology to Gene Therapy
Hair restoration has evolved from surgery to drugs to potential gene therapy, with improved results and ongoing research driven by high demand.
research Cooling-mediated protection from chemotherapy drug-induced cytotoxicity in human keratinocytes by inhibition of cellular drug uptake
Cooling can protect hair follicles from chemotherapy damage by reducing drug uptake.
research Clinicopathological characteristics and treatment outcomes of fibrosing alopecia in a pattern distribution: A retrospective cohort study
Early treatment of fibrosing alopecia in a pattern distribution may improve outcomes.
research Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential
IGF-1 can help regrow hair and may be a promising treatment for hair loss.
research Congenital and Hereditary Skin Diseases
Bovines can have rare inherited skin diseases with specific symptoms like hair loss, fragile skin, and abnormal porphyrin buildup.
research Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro
Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.
research Loss of ‘Epidermal Melanin Unit’ Integrity in Human Skin During Melanoma-Genesis
Melanoma development can be linked to the breakdown of skin's melanin-producing units.
research [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies].
Keratinocytes in hair follicles differentiate similarly to skin cells, with specific patterns in different regions.
research [Three-dimensional culture of plucked human hair follicles inside the collagen gel matrix].
Human hair follicles can grow and form structures in a collagen gel, useful for studying hair cell growth.
research Frontal fibrosing alopecia versus lichen planopilaris: a clinicopathological study
The conclusion is that FFA and LPP have similar scalp biopsy features, making them hard to distinguish histologically, and FFA may be a specific kind of scarring hair loss.
research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes
Hairless protein can block vitamin D activation in skin cells.