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GlossaryHair Growth Factors

naturally occurring proteins that stimulate hair follicle growth

Hair Growth Factors are naturally occurring proteins or compounds that stimulate hair follicles to enter the growth phase, promoting hair development and reducing hair loss. These factors, such as keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF), play crucial roles in cellular signaling pathways that regulate the hair growth cycle, making them essential in both clinical treatments for alopecia and cosmetic hair care products.

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research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

research Local Injection of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) Alters Cyclic Growth of Murine Hair Follicles

109 citations , April 1998 in “Journal of Investigative Dermatology”

HGF/SF injections can stimulate hair growth and increase hair follicle size in mice.

research Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.

107 citations , June 1997 in “PubMed”

EGFR is essential for normal hair development and follicle differentiation.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

research Epidermal Growth Factor as a Biologic Switch in Hair Growth Cycle

94 citations , July 2003 in “Journal of biological chemistry/The Journal of biological chemistry”

EGF controls hair growth by regulating hair follicles' growth phases.

research GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE

90 citations , October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation

77 citations , February 2001 in “Journal of Dermatological Science”

HGF activator helps convert HGF to its active form, promoting hair growth.

Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

research Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

Certain growth factors can promote hair growth in mice by activating hair growth-related proteins.

research In vivo promoted growth of mice hair follicles by the controlled release of growth factors

60 citations , April 2003 in “Biomaterials”

Controlled release of growth factors in hydrogels improved hair growth in mice.

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.

research Hair Growth Induction: Roles of Growth Factors

44 citations , December 1991 in “Annals of the New York Academy of Sciences”

EGF and FGF help hair growth by affecting cell differentiation and fiber growth.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats

42 citations , September 2015 in “Gene”

FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.

research The Cutaneous Epidermal Growth Factor Network: Can it be Translated Clinically to Stimulate Hair Growth?

39 citations , March 2009 in “Dermatology Online Journal”

Understanding EGFR roles could lead to new hair loss treatments.

research A role of placental growth factor in hair growth

31 citations , February 2014 in “Journal of dermatological science”

Placental growth factor may help treat hair loss.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research Enhancing hair growth in male androgenetic alopecia by a combination of fractional CO2 laser therapy and hair growth factors

26 citations , May 2017 in “Lasers in Medical Science”

Laser therapy and hair growth factors significantly improve hair density in male baldness.

research Narrow-band red LED light promotes mouse hair growth through paracrine growth factors from dermal papilla

23 citations , September 2011 in “Journal of Dermatological Science”

Red LED light helps mouse hair grow by increasing growth factors from skin cells.

research Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth

19 citations , May 2016 in “Clinical, cosmetic and investigational dermatology”

FGF-2&D/P nanoparticles can help treat hair loss.

Intradermal Injections of a Hair Growth Factor Formulation for Enhancement of Human Hair Regrowth: Safety and Efficacy Evaluation in a First-in-Man Pilot Clinical Study

research Intradermal injections of a hair growth factor formulation for enhancement of human hair regrowth – safety and efficacy evaluation in a first-in-man pilot clinical study

17 citations , February 2018 in “Journal of Cosmetic and Laser Therapy”

The QR 678 hair growth treatment was safe and effective for hair regrowth in men and women.

research Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed

17 citations , April 2021 in “Molecules/Molecules online/Molecules annual”

Linoleic acid from Malva verticillata seeds may help treat hair loss by promoting hair cell growth and blocking baldness signals.

Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades

research Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades

14 citations , January 2016 in “Biochemical and Biophysical Research Communications”

Ginsenoside Re from ginseng may help hair grow by blocking a specific growth-inhibiting pathway.

research Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7

13 citations , July 2016 in “BMC Complementary and Alternative Medicine”

Hominis Placenta helps hair grow back by increasing cell growth and a specific growth factor.

research Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro

9 citations , March 1987 in “British Journal of Dermatology”

EGF and FGF can boost hair growth by speeding up cell growth.

research Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells

8 citations , October 2020 in “International Journal of Molecular Sciences”

Nonanal from fruits and vegetables promotes hair growth by increasing growth factors.

Antisense Oligonucleotide Targeting Fibroblast Growth Factor Receptor-1 Stimulates Cellular Activity of Hair Follicles in an In Vitro Organ Culture System

research Antisense oligonucleotide targeting fibroblast growth factor receptor (FGFR)-1 stimulates cellular activity of hair follicles in anin vitroorgan culture system

7 citations , March 2007 in “International Journal of Dermatology”

Targeting FGFR-1 with antisense oligonucleotides may help treat baldness by increasing hair follicle activity.

research Transforming growth factor-alpha immunoreactivity during induced hair follicle growth cycles in sheep and ferrets.

6 citations , April 1996 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

TGF-alpha is present in sheep and ferret skin and may affect hair growth without directly stimulating cell proliferation.

Pinus Thunbergii Bark Extract Rich in Flavonoids Promotes Hair Growth in Dorsal Skin by Regulating Inflammatory Cytokines and Increasing Growth Factors in Mice

research Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice

5 citations , January 2022 in “Molecular Medicine Reports”

Pine bark extract helps mice grow hair by reducing inflammation and boosting growth factors.

The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and Beta-Catenin in Hair Follicle Cells

research The potential role of fibroblast‐derived multi‐peptide factors in activation of growth factors and β‐Catenin in hair follicle cells

4 citations , June 2022 in “Journal of Cosmetic Dermatology”

Multi-peptide factors from fibroblasts may stimulate hair growth by increasing growth factors and β-catenin in hair cells.

Evaluation of Efficacy of QR 678 and QR678 Neo Hair Growth Factor Formulation for the Treatment of Female Pattern Alopecia in Patients with PCOS—A Prospective Study

research Evaluation of efficacy of QR 678 and QR678 neo hair growth factor formulation for the treatment of female pattern alopecia in patients with PCOS—A prospective study

4 citations , August 2020 in “Journal of Cosmetic Dermatology”

QR 678 and QR678 Neo treatments are effective for hair loss in women with PCOS.

More Is Not Always Better in Hair Growth Factors: Epidermal Growth Factor Involved in Alopecia Areata Pathogenesis

research More is not always better in hair growth factors. epidermal growth factor: hair growth factor involved in alopecia areata pathogenesis

4 citations , January 2020 in “International Journal of Trichology”

Too much epidermal growth factor can cause hair loss.