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GlossaryIrritation

state of inflammation or discomfort in body tissues

Irritation refers to a state of inflammation or discomfort in a part of the body, often caused by external factors like chemicals, physical abrasion, or allergens. In the context of the scalp and hair, irritation can manifest as redness, itching, or a burning sensation, potentially leading to conditions like dermatitis or exacerbating hair loss issues such as alopecia.

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research UJI IRITASI DAN AKTIVITAS PERTUMBUHAN RAMBUT TIKUS PUTIH: EFEK SEDIAAN GEL APIGENIN DAN PERASAN HERBA SELEDRI (Apium graveolens L.) THE IRRITATION AND HAIR GROWTH ACTIVITY TEST OF MALE S-D MICE: EFFECT OF GEL CONTAINING APIGENIN AND CELERY (APIUM GRAVEOLENS L.) JUICE

1 citations , January 2015

The gel with apigenin and celery juice promotes hair growth without causing skin irritation.

Physical Stability Test of Hair Tonic with Cinnamon Essential Oil and Virgin Coconut Oil Using Cycling Test Method and Irritation Test on Rabbits

research PHYSICAL STABILITY TEST HAIR TONIC COMBINATION Cinnamon (Cinnamomum burmanii) ESSENTIAL OIL AND VCO (VIRGIN COCONUT OIL) WITH CYCLING TEST METHOD AND IRRITATION TEST ON THE RABBIT

May 2023 in “Jurnal farmasi sains dan praktis”

The hair tonic with cinnamon oil and coconut oil was stable and caused very mild irritation.

research The analysis of scalp irritation by coacervates produced in hair shampoo via FTIR with focal plane array detector, X‐ray photoelectron microscopy and HaCaT cells

5 citations , August 2016 in “International Journal of Cosmetic Science”

Shampoo coacervates can cause scalp irritation due to released surfactants.

research Permanent Hair Waving

February 2022 in “Cosmetic Dermatology”

Permanent hair waving uses chemicals to create long-lasting curls.

research Temporary hair removal in patients with hirsutism: a clinical study.

89 citations , March 1990 in “PubMed”

Shaving is the most effective temporary hair removal method for facial hirsutism.

research Topically applied glycyrrhizic acid causes hair removal in rats

4 citations , May 2014 in “Pharmaceutical Biology”

Glycyrrhizic acid from sweet licorice can effectively remove hair without skin irritation.

research Healing hair naturally: A focus on herbal treatment for hair disorders

January 2025 in “International Journal of Pharmacognosy and Life Science”

Herbal treatments like Aloe vera, Bhringraj, Neem, Tea tree oil, Amla, and Hibiscus are promising for safer, effective hair care.

research Toxic Truths of commercial hair oils and healing oils of Ayurveda

January 2025 in “International journal of Indian medicine”

Use pure Ayurvedic oils instead of commercial ones for healthier hair.

research Hair care products: waving, straightening, conditioning, and coloring

150 citations , July 2001 in “Clinics in dermatology”

Proper haircare and communication with doctors are key to managing hair loss and avoiding damage.

research Hair Pain (Trichodynia): Frequency and Relationship to Hair Loss and Patient Gender

48 citations , January 2002 in “Dermatology”

Hair pain is more common in women with hair loss, but it's not linked to the cause or severity of hair loss.

research Waterborne polyurethanes from castor oil-based polyols for next generation of environmentally-friendly hair-styling agents

25 citations , May 2020 in “Progress in Organic Coatings”

Castor oil-based polyurethanes are promising for making safe, strong-performing, eco-friendly hair-styling products.

Hair Regrowth in Two Patients with Recalcitrant Central Centrifugal Cicatricial Alopecia After Use of Topical Metformin

research Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin

24 citations , January 2020 in “JAAD Case Reports”

Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.

Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations , June 2017 in “Journal of pharmaceutical sciences”

Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.

research Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery

15 citations , February 2014 in “Toxicology Letters”

Coumarin derivatives cause skin irritation, but coumarin itself does not.

research Platelet-rich plasma microneedling versus 5% topical minoxidil in the treatment of patterned hair loss

13 citations , January 2016 in “Journal of the Egyptian Women's Dermatologic Society (Print)”

Minoxidil works faster and is more cost-effective for treating hair loss, but platelet-rich plasma microneedling can be an alternative for those who can't use minoxidil.

research Topical and oral minoxidil for hair disorders in pediatric patients: What do we know so far?

12 citations , July 2020 in “Dermatologic Therapy”

Minoxidil, applied on the skin or taken orally, can improve hair growth in kids, but more research is needed due to possible side effects.

research The pH of lye and no-lye hair relaxers, including those advertised for children, is at levels that are corrosive to the skin

12 citations , November 2019 in “South African Medical Journal”

Lye and no-lye hair relaxers can damage skin.

research Establishment of a new three‐dimensional human epidermal model reconstructed from plucked hair follicle‐derived keratinocytes

12 citations , May 2016 in “Experimental Dermatology”

A new skin model from hair follicles is a safer, simpler alternative for skin tests.

research In vivo and in vitro hair growth‐promoting effect of silver and iron nanoparticles synthesized via Blumea eriantha DC plant extract

11 citations , September 2020 in “Journal of Cosmetic Dermatology”

Silver nanoparticles can significantly promote hair growth.

research Formulation and Evaluation of Herbal Hair Dye: An Ecofriendly Process

9 citations , January 2010

The herbal hair dye is a safe and eco-friendly alternative to conventional dyes.

research Adipose and Hair Function: An aPPARent Connection

7 citations , February 2018 in “Journal of Investigative Dermatology”

Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.

research Smoothened antagonists for hair inhibition

7 citations , June 2010 in “Bioorganic & medicinal chemistry letters”

Two new compounds were found to effectively reduce hair growth in mice.

research USING HAIR GROWTH ACTIVITY, PHYSICAL STABILITY, AND SAFETY TESTS TO STUDY HAIR TONICS CONTAINING ETHANOL EXTRACT OF LICORICE (GLYCYRRHIZA GLABRA LINN.)

4 citations , October 2017 in “International Journal of Applied Pharmaceutics”

Licorice extract hair tonics are effective and safe for hair growth, except for mild eye irritation at the lowest concentration.

research Ficus benghalensis as Potential Inhibitor of 5α-Reductase for Hair Growth Promotion: In Vitro, In Silico, and In Vivo Evaluation

3 citations , December 2021 in “Frontiers in Pharmacology”

Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.

research HAIR TONIC OF BROCCOLI (BRASSICA OLERACEA VAR. ITALICA) EXTRACT: FORMULATION, PHYSICAL CHARACTERISTIC, STABILITY AND HAIR GROWTH ACTIVITY TEST

2 citations , August 2024 in “International Journal of Applied Pharmaceutics”

Broccoli extract hair tonic effectively promotes hair growth and is safe to use.

research Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative?

2 citations , March 2022 in “Journal of Cosmetic Dermatology”

Topical finasteride is a safe and effective treatment for pattern hair loss with fewer side effects than oral finasteride.

research Optimization and Transfollicular Delivery of Finasteride-Loaded Proniosomes for Hair Growth Stimulation in C57BL/6Mlac Mice

2 citations , December 2021 in “Pharmaceutics”

Finasteride-loaded proniosomes effectively promote hair growth in mice.