140 citations
,
December 1998 in “Journal of Investigative Dermatology” Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.
109 citations
,
June 2000 in “Development” Notch pathway activation causes abnormal hair layer development.
105 citations
,
December 1998 in “Archives of Dermatological Research” Dermal papilla cells mainly drive blood vessel growth in hair follicles.
103 citations
,
January 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
95 citations
,
July 2006 in “British Journal of Dermatology” Vitamin D receptors in hair follicles change with the hair cycle, affecting hair growth.
88 citations
,
May 2005 in “Journal of Dermatological Science” Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
86 citations
,
August 2000 in “Pigment cell research” Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
85 citations
,
June 2017 in “Journal of Investigative Dermatology” Blimp1 is crucial for hair follicle growth and skin health.
78 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
77 citations
,
February 2001 in “Journal of Dermatological Science” HGF activator helps convert HGF to its active form, promoting hair growth.
72 citations
,
January 1983 in “The Anatomical Record” Epidermal growth factor delays skin and hair development in mice.
67 citations
,
February 1994 in “Developmental dynamics” Specific proteins and molecules play key roles in the development of human hair follicles.
65 citations
,
February 1992 in “Development” Type II keratin genes are crucial for hair follicle differentiation and have a conserved structure and expression pattern.
63 citations
,
January 1992 in “Experimental Neurology” Chickens exposed to loud noise can quickly regain hearing mostly due to repair of the tectorial membrane, not just hair cell regeneration.
61 citations
,
November 2004 in “Annals of the Academy of Medicine Singapore” Hair follicle stem cells are mainly in the bulge region and can help repair skin and form hair and glands, but more research is needed to fully understand them.
60 citations
,
August 2005 in “Endocrinology” αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.
58 citations
,
December 1992 in “British Journal of Dermatology” Rat hair follicles grow longer in vitro, but certain factors can inhibit this growth.
53 citations
,
September 2013 in “Journal of Investigative Dermatology” Hair follicle cells help protect against immune attacks by regulating T-cell activity.
53 citations
,
April 1985 in “Developmental Biology” Fibronectin and other basement membrane components increase during hair growth and decrease during rest.
52 citations
,
September 2017 in “Current Stem Cell Research & Therapy” Adipose-derived stem cells can help treat hair loss.
46 citations
,
November 1998 in “Experimental Cell Research” K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.
45 citations
,
August 1992 in “PubMed” The rat vibrissa follicle can quickly remodel its basement membrane during hair growth, affecting cell signaling and activity.
41 citations
,
November 2013 in “Experimental Dermatology” Leptin, a hormone, is important for starting hair growth.
41 citations
,
January 2007 in “Journal of Korean Medical Science” Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.
40 citations
,
November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Different melanocyte types in hair follicles either survive or die during the catagen phase.
37 citations
,
June 1996 in “Journal of cellular physiology” Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.
36 citations
,
April 2016 in “Biochimie” A substance called epidermal growth factor helps increase the growth of important hair follicle cells by activating a specific cell communication route.
35 citations
,
July 2018 in “Cell Reports” The study found that a specific area of the hair follicle helps start hair growth by reducing the blocking effects on certain cells and controlling growth signals.
33 citations
,
August 2015 in “F1000Research” New model shows muscle affects hair loss differently in men and women.
31 citations
,
July 2022 in “Advanced healthcare materials/Advanced Healthcare Materials” A drug-free microneedle patch significantly promotes hair growth and prevents infections.