450 citations
,
January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
397 citations
,
February 2004 in “British Journal of Dermatology” Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
303 citations
,
August 1971 in “The American Journal of Medicine” Melanocytes are destroyed by factors needed for melanin production, causing vitiligo and gray hair.
210 citations
,
May 2006 in “The FASEB journal” Oxidative stress causes hair to gray by damaging and killing pigment cells.
202 citations
,
August 2017 in “Nature cell biology” Lactate production is important for activating hair growth stem cells.
161 citations
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June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair stops producing melanin as it transitions from the growth phase to the resting phase.
152 citations
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December 2003 in “Micron” As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
122 citations
,
December 2022 in “International Journal of Molecular Sciences” Nanoparticles improve skin treatment but need more research on safety and effectiveness.
104 citations
,
October 1999 in “The Journal of Urology” Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.
86 citations
,
July 2020 in “International Journal of Molecular Sciences” Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.
86 citations
,
August 2000 in “Pigment cell research” Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
75 citations
,
January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
73 citations
,
October 2013 in “International Journal of Cosmetic Science” Chemical hair straightening can damage hair and health, needing safer alternatives and stricter regulations.
60 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Applying a specific inhibitor lightens skin and hair color.
55 citations
,
April 2015 in “BMC medicine” Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.
50 citations
,
September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids” Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.
46 citations
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September 2014 in “Tissue engineering. Part A” Researchers created hair-inducing human cell clusters using a 3D culture method.
40 citations
,
June 2011 in “Journal of biological chemistry/The Journal of biological chemistry” FA2H is essential for normal fur and sebum production in mice.
38 citations
,
September 2014 in “Cell and Tissue Research” The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.
35 citations
,
January 2011 in “Journal of Biological Chemistry” sPLA2-X is crucial for normal hair growth and follicle health.
34 citations
,
January 1943 in “Endocrinology” Adrenalectomy boosts hair growth and melanin in black rats, even with vitamin B¹ deficiency.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” Oral zinc sulphate reduces dark hair color in mice.
27 citations
,
April 2020 in “Molecular Biology and Evolution” Ancient Chinese goats evolved cashmere-producing traits due to selective breeding, particularly in genes affecting hair growth.
26 citations
,
January 2018 in “Annals of dermatology/Annals of Dermatology” Hair graying may be caused by stem cell depletion from stress or melanocyte damage.
24 citations
,
November 2019 in “Experimental Dermatology” PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.
20 citations
,
August 2017 in “Drug testing and analysis” Drugs localize differently in hair strands based on their properties.
20 citations
,
January 2015 in “Current problems in dermatology” Graying hair happens due to aging and might be delayed by new treatments.
20 citations
,
January 1995 in “Cells tissues organs” Changing light periods synchronized wool growth cycles in sheep.
19 citations
,
January 2012 in “Dermato-endocrinology” Moderately high prolactin levels do not cause hair loss in women.
18 citations
,
September 2018 in “Current Pharmaceutical Design” Some medicinal plants may treat hair loss with fewer side effects.