122 citations
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March 2013 in “Expert opinion on drug delivery” Optimizing drug delivery to hair follicles is crucial for effective treatment.
100 citations
,
May 2006 in “American Journal Of Pathology” Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.
92 citations
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August 2017 in “Proceedings of the National Academy of Sciences of the United States of America” Newborn mouse skin cells can grow hair and this process can be recreated in adult cells to potentially help with hair loss.
75 citations
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January 2009 in “International journal of trichology” Hair grays due to oxidative stress and fewer functioning melanocytes.
71 citations
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June 2001 in “American Journal of Pathology” The p53 protein helps control hair follicle shrinking by promoting cell death in mice.
62 citations
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July 1993 in “Journal of Investigative Dermatology” Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
60 citations
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November 2013 in “Development” Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.
52 citations
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October 2004 in “Veterinary dermatology” Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.
47 citations
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December 2011 in “Experimental Dermatology” CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.
40 citations
,
June 2009 in “Journal of Cutaneous Pathology” AGA patients have fewer hairs and smaller follicles; T:V ratio above 4:1 may indicate AGA.
38 citations
,
June 2005 in “Acta Biochimica Polonica” Splenic eumelanin in C57BL/6 mice is different from hair eumelanin.
37 citations
,
September 2008 in “The American journal of surgical pathology” Hair follicle hyperplasia is common in both benign and malignant skin lymphoproliferative disorders, with a proposed new term "pseudolymphomatous adnexitis."
32 citations
,
May 2016 in “European journal of dermatology/EJD. European journal of dermatology” Targeted therapies for advanced skin cancer often cause hair and nail problems, which need managing to avoid changing the treatment dose.
31 citations
,
October 2012 in “Archives of ophthalmology” Laser hair reduction near the eyebrows can cause serious eye injuries even with safety measures.
30 citations
,
December 2018 in “Trends in Endocrinology and Metabolism” Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.
26 citations
,
August 2019 in “Stem Cell Research & Therapy” PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.
26 citations
,
January 2018 in “Annals of dermatology/Annals of Dermatology” Hair graying may be caused by stem cell depletion from stress or melanocyte damage.
26 citations
,
November 2016 in “European Journal of Clinical Pharmacology” Valproic acid helps delay hair loss and increases survival time for high-grade glioma patients undergoing radiation therapy.
24 citations
,
January 2015 in “Annals of Dermatology” Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.
21 citations
,
May 2018 in “Journal of Cosmetic Dermatology” Costunolide helps human hair cells grow and can stimulate hair growth in mice.
20 citations
,
October 2013 in “British Journal of Dermatology” The document concludes that clinicians should be aware of common hair and scalp disorders in women of African descent and that more research is needed to develop effective treatments.
19 citations
,
August 1998 in “Journal of the American Academy of Dermatology” Hair loss can signal serious health issues, not just cosmetic concerns.
19 citations
,
December 2018 in “Experimental and Molecular Medicine” Small molecule IM boosts hair growth by changing stem cell metabolism.
19 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” Human hair follicles can regenerate and recover after severe injury by going through a brief abnormal resting phase before growing again.
18 citations
,
September 2018 in “Current Pharmaceutical Design” Some medicinal plants may treat hair loss with fewer side effects.
17 citations
,
May 2021 in “Journal of Cell Science” N1-acetylspermidine promotes hair follicle stem cell self-renewal.
16 citations
,
January 2002 in “Dermatology” Early baldness is noticed due to both reduced hair density and thinner hair shafts.
14 citations
,
May 2014 in “Archives of plastic surgery” The position of the parietal whorl can predict safe donor areas for hair transplants in Korean men with male pattern baldness.
13 citations
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March 2013 in “Dermatologic Surgery” The document concludes that hair restoration has advanced significantly, with FUE becoming more popular, and stresses the importance of physician training and ethical practices in the field.
13 citations
,
March 2020 in “Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy” Alopecic hair has more irregular structures and chemical changes than normal hair, reducing its strength.