508 citations
,
February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
434 citations
,
October 2003 in “PTR. Phytotherapy research/Phytotherapy research” Natural products in cosmetics are beneficial for skin and hair care with low toxicity.
299 citations
,
January 2018 in “Journal of Clinical Investigation” Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
290 citations
,
December 2017 in “Journal of The American Academy of Dermatology” Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
263 citations
,
February 2013 in “Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology” Polymeric nanoparticles show promise for treating skin diseases.
260 citations
,
December 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
211 citations
,
June 2012 The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
198 citations
,
October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft” Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.
156 citations
,
January 1989 in “Genes & Development” Keratin expression reflects cell organization and differentiation, not causes it.
156 citations
,
August 2016 in “Journal of controlled release” Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.
134 citations
,
January 2011 in “Development” Adam10 enzyme is crucial for healthy skin and proper Notch signaling.
131 citations
,
March 2004 in “The American journal of pathology” Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.
127 citations
,
January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
124 citations
,
February 2018 in “Nature Reviews Genetics” Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.
124 citations
,
December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
120 citations
,
October 2007 in “Clinical Interventions in Aging” Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.
109 citations
,
September 2011 in “Human molecular genetics online/Human molecular genetics” New treatments targeting specific genes show promise for treating keratin disorders.
106 citations
,
April 2013 in “Dermatologic Surgery” Low-level light therapy safely improves hair growth and thickness for androgenetic alopecia.
105 citations
,
April 2004 in “Dermatologic Therapy” The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
81 citations
,
September 2005 in “The American journal of pathology” Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.
75 citations
,
March 2009 in “Journal of The American Academy of Dermatology” CCCA is a hair loss type affecting African women, possibly caused by grooming and chemicals, with various treatments and needing more research.
72 citations
,
July 2008 in “Dermatologic Therapy” CCCA is a scarring hair loss condition mainly in African descent women, possibly caused by genetics and hairstyling, treated with gentle hair care and medications.
71 citations
,
January 2004 in “Dermatology” Oral finasteride works better than topical minoxidil for hair growth, both are safe.
67 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Chronic Telogen Effluvium may resolve after years and is diagnosed by examining the patient's history and clinical signs, with treatment aimed at underlying causes and possibly minoxidil.
67 citations
,
November 2002 in “Journal of The American Academy of Dermatology” The document concludes that careful evaluation is key to diagnose and treat women with hair loss, with tests for thyroid, iron, and hormones as needed.
65 citations
,
February 2017 in “Pflügers Archiv - European Journal of Physiology” Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.
62 citations
,
April 2009 in “British Journal of Dermatology” Epidermal stem cells could lead to new treatments for skin and hair disorders.
60 citations
,
April 2018 in “Clinical, cosmetic and investigational dermatology” Tight hairstyles and chemical relaxers can cause hair loss known as traction alopecia.