research Hair Loss Diagnosis and Treatment Knowledge Based System
Hair loss causes emotional distress, leading to high spending on treatments, with Minoxidil and Propecia being common but having side effects.
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research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth
Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.
research Tooth Development Associated with Mutations in Hereditary Vitamin D–Resistant Rickets
Early detection of specific VDR mutations is crucial for effective treatment and better dental outcomes in children with hereditary vitamin D–resistant rickets.
research Editorial: Vitamin D 1α-Hydroxylase Knockout Mice as a Hereditary Rickets Animal Model
The editorial discussed the role of vitamin D 1α-hydroxylase (CYP27B1) in mineral homeostasis and bone formation, highlighting its importance in converting vitamin D3 into its active form, 1α,25(OH)2D3. The study by Dardenne et al. introduced knockout mice lacking 1α(OH)ase, which developed rickets and osteomalacia, similar to vitamin D-dependent rickets type I (VDDRI) patients. These mice showed decreased serum calcium and 1α,25(OH)2D3 levels, confirming the enzyme's critical role in vitamin D metabolism. Unlike VDR knockout mice, 1α(OH)ase knockout mice did not develop alopecia, emphasizing the distinct roles of VDR and 1α(OH)ase in hair follicle development. The study suggested potential species differences in vitamin D metabolism and raised questions about the enzyme's roles in extra-renal tissues and tumors.
research A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid function tests, zinc, copper, biotin, and selenium levels
Telogen effluvium is linked to deficiencies in iron, vitamin B12, and thyroid function.
research Efficacy of Intralesional Vitamin D in the Treatment of Alopecia Areata Using Dermoscopy before and after Treatment
Intralesional vitamin D is mildly effective for treating Alopecia Areata.
research Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and immunohistochemical study
Laser treatment, especially when combined with other therapies, is effective for hair regrowth in alopecia areata.
research Retrospective Assessment of Changes in Perceived Health Status during Continuous Use of a Dietary Supplement
Most people using the supplement Renew saw health improvements, especially in sleep and energy, faster than with regular vitamins.
research Data for the article "Increased calcidiol level in redhaired people: Could redheadedness be an adaptation to temperate climate?"
Redheaded people have higher levels of vitamin D precursor, suggesting their hair color may be an adaptation to low sunlight areas.
research Reduced Ferritin, Folate and Vitamin B12 Levels in Female Patients Diagnosed With Telogen Effluvium
Women with telogen effluvium have lower levels of iron, folate, and vitamin B12.