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research Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour

28 citations , September 2013 in “European Journal of Histochemistry”

Keratins in Malayan pangolins vary by region, suggesting scales evolved from the tail towards the head.

research Special issue on epidermal and hair follicle differentiation, part 2

December 2004 in “Differentiation”

research Characterization of a Hair (Wool) Keratin Intermediate Filament Gene Domain

40 citations , February 1994 in “Journal of Investigative Dermatology”

research Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans

38 citations , October 2001 in “British Journal of Dermatology”

Keratin K6irs is a marker for the inner root sheath of hair follicles in mice and humans.

research Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification

12 citations , June 2013 in “International Journal of Dermatology”

Seborrheic keratosis shows varied cell differentiation, and keratin analysis helps diagnose skin tumors.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

research Beauty is skin deep: the fascinating biology of the epidermis and its appendages.

65 citations , December 2000 in “PubMed”

The biology of skin and hair is complex and not fully understood.

research Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles

34 citations , June 2008 in “In vitro cellular & developmental biology. Animal”

Scientists created a long-lasting stem cell line from human hair that can turn into different skin and hair cell types.

research Dermal papilla cells induce keratinocyte tubulogenesis in culture Elina S. ChermnykhEkaterina A. VorotelyakKsenia Y. Gnedeva • Marianna V. MoldaverYegor E. YegorovAndrey V. Vasiliev •

January 2010

Dermal papilla cells can help form hair-like structures in lab-grown skin cells.

research Hair structure anatomy and comparative anatomy1 1Dedicated to the memory of the late Dr. R. E. Rivett whose untimely death prevented his role in co-authorship.

50 citations , March 2001 in “Clinics in dermatology”

Human hair is complex and grows in cycles starting from embryonic life.

research Protein chains in hair and epidermal keratin IF: Structural features and spatial arrangements

5 citations , January 1997 in “Birkhäuser Basel eBooks”

research A group of type I keratin genes on human chromosome 17: characterization and expression.

141 citations , February 1988 in “Molecular and Cellular Biology”

Only one K16 gene on chromosome 17 makes a functional keratin protein.

research Evolution of Trichocyte Keratins

18 citations , January 2018 in “Advances in experimental medicine and biology”

Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.

research Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin

49 citations , July 2006 in “British Journal of Dermatology”

Calcifying epithelioma cells can differentiate into hair cortex and outer root sheath.

research Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells

62 citations , June 1993 in “Archives of Dermatological Research”

research No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles

7 citations , March 2018 in “Experimental Dermatology”

Acne lesions don't show increased keratinocyte growth compared to healthy hair follicles.

research Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin.

2 citations , January 1989 in “The Nishinihon Journal of Dermatology”

Seborrheic keratosis likely originates from the upper regions of hair follicles.

research Multifaceted role of keratins in epithelial cell differentiation and transformation

50 citations , April 2019 in “Journal of Biosciences”

research Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds

1 citations , June 2009 in “WakeSpace (Wake Forest University)”

Keratin biomaterials can effectively aid peripheral nerve regeneration and improve recovery.

research Human hair keratins promote the regeneration of peripheral nerves in a rat sciatic nerve crush model

36 citations , July 2019 in “Journal of Materials Science Materials in Medicine”

Human hair keratin helps repair nerve damage in rats.

research Formation of surface membranes in developing mammalian hair fibres

30 citations , January 1994 in “Micron”

Mature hair surfaces are formed by keratinized cells with developed layers, not just modified plasma membranes.

research Abstract 5020: Characterization of epidermal stem cells in SKH1 hairless mice, a widely used mouse model to investigate ultraviolet radiation carcinogenesis.

April 2013 in “Cancer Research”

SKH1 hairless mice have identifiable epidermal stem cells with specific markers.

research Revisiting the significance of keratin expression in complex epithelia

6 citations , October 2022 in “Journal of cell science”

Keratin genes change gradually during skin cell development and should be used carefully as biomarkers.

research Localization of Merkel cells at hairless and hairy human skin sites using keratin 18

28 citations , September 1995 in “Biochemistry and Cell Biology”

Merkel cells are more densely found in hairless skin areas like palms and soles.

research Sequence and expression of human hair keratin genes

19 citations , July 1994 in “Journal of Dermatological Science”

Human hair keratin genes are similar to mouse genes and are specifically expressed in hair follicles.

research Structure and functions of human hair keratin

January 2003 in “Swinburne Research Bank (Swinburne University of Technology)”

research Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis

February 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Keratin 15 helps keep skin cells in a young, undifferentiated state.

research Presentations of Cutaneous Disease in Various Skin Pigmentations: Keratosis Pilaris

February 2026 in “HCA Healthcare Journal of Medicine”

Recognizing keratosis pilaris in all skin tones helps diagnose related skin issues and reduce distress.

research Skin structure

March 2015 in “Plastic and reconstructive surgery”

Human skin has multiple layers and functions, with key roles in protection, temperature control, and appearance.

research Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10.

13 citations , July 1994 in “PubMed”

Keratins K6 and K16 are expressed more freely in regenerating mouse skin than K1 and K10.

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