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research From Primary MSC Culture of Adipose Tissue to Immortalized Cell Line Producing Cytokines for Potential Use in Regenerative Medicine Therapy or Immunotherapy

13 citations , October 2021 in “International Journal of Molecular Sciences”

The HATMSC1 cell line from fat tissue can produce helpful factors for regenerative and immune therapies.

research Embryonic development of hair follicle pluripotent stem (hfPS) cells

11 citations , June 2010 in “Medical Molecular Morphology”

research GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis

24 citations , December 2013 in “Archives of Dermatological Research”

research [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector].

February 2014 in “PubMed”

Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

Spheroid Cell Cultures as a Promising Study Model for Hair Follicle Regeneration

research 1333 Spheroids cell cultures as a promising study model for hair follice regeneration

April 2018 in “Journal of Investigative Dermatology”

Culturing Dermal Papilla Cells and Hair Follicle Stem Cells in 3D conditions can significantly improve hair regeneration potential.

research Histopathological Analysis on keratin2-6 g Expression in Hair Mutant Mouse Hague

January 2002 in “Proceedings of The Japanese Society of Animal Models for Human Diseases”

Keratin2-6g is crucial for hair follicle development, with mutations causing cell degeneration and vacuolation.

research Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

January 2012 in “Infoscience (Ecole Polytechnique Fédérale de Lausanne)”

Human thymus has stem cells that can self-renew and maintain their identity.

research Human hair-follicle associated pluripotent (HAP) stem cells differentiate to cardiac muscle cells

April 2017 in “Journal of dermatological science”

Human hair follicles can produce stem cells that turn into heart muscle cells.

research Characterization and isolation of stem cell-enriched human hair follicle bulge cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function

September 2017 in “Journal of Investigative Dermatology”

Activating the hexosamine pathway can improve skin health and increase hair follicle stem cells.

research The combination of hair follicle-specific marker LHX2 and co-expressed marker can distinguish between sweat gland placodes and hair placodes in rat

5 citations , September 2021 in “Journal of Molecular Histology”

LHX2, with other markers, can identify hair placodes in rats.

research A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle

86 citations , May 2002 in “Journal of Investigative Dermatology”

A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

research A hairy kinase

August 2005 in “The Journal of Cell Biology”

Sgk3 kinase is essential for normal hair growth in mice.

research Faculty Opinions recommendation of Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.

November 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Keratin 79 cells help form and regenerate hair canals.

research 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia

1 citations , November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders

March 2026 in “Experimental Dermatology”

The new model helps understand and develop treatments for genetic skin disorders like AEC.

Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

research Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells

6 citations , July 2012 in “Experimental Dermatology”

The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.

A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

research A model system to analyse the ability of human keratinocytes to form hair follicles

15 citations , April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes

27 citations , February 2003 in “European Journal Of Oral Sciences”

SVpgC2a cells show abnormal growth and keratin changes, modeling early cancer development.

research The patch assay reconstitutes mature hair follicles by culture-expanded human cells

11 citations , July 2017 in “Regenerative Medicine”

The patch assay can create mature hair follicles from human cells and may help in hair loss treatments.

K15 And Id3 Expression In Intact And Regenerating Adult Vibrissae Rodent Hair Follicles

research K15 & Id3 expression in intact and regenerating adult vibrissae rodent hair follicles

January 2009

K15 and Id3 are important in hair follicle regeneration, with K15 increasing in early stages and Id3 responding later.

Nestin as a Marker of Unipotent Epithelial Progenitor Cells Differentiating into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles

June 2022 in “Research Square (Research Square)”

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

research Identification of Bulge Stem Cells in Mouse and Human Hair Follicles

4 citations , January 2018 in “Microscopy research”

Scientists found markers called CD34 and CD200 that help identify stem cells in mouse and human hair follicles.

research Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells

3 citations , July 2017 in “Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model”

Mouse hair follicle stem cells have a flexible chromatin state that supports skin health and hair growth.

research Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel

7 citations , July 2016 in “Journal of Biomedical Materials Research Part A”

cGEL hydrogel improves melanin production in skin cells, making it a promising option for skin treatments.

research Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice

12 citations , June 2012 in “Wound Repair and Regeneration”

Regulating keratinocyte growth in engineered skin can improve wound healing.

research Discovery of HAP Stem Cells

January 2016 in “Methods in molecular biology”

HAP stem cells in hair follicles could help repair nerves and spinal cords.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle

14 citations , February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

research Isolation, Cultivation, and Morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in Mouse and Human

1 citations , January 2020 in “Microscopy research”

Researchers successfully grew hair follicle stem cells from mice and humans, which could be useful for tissue engineering and regenerative medicine.

Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration

research Three-Dimensional Cultured Human Dermal Papilla Cells in HGC-Coated Environments Enhance Hair Regeneration and Artificial Skin Integration

January 2024 in “Biomaterials Research”

3D-cultured cells in HGC-coated environments improve hair growth and skin integration.

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