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Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

Network Analysis Reveals Potential Mechanisms That Determine the Cellular Identity of Keratinocytes and Corneal Epithelial Cells Through the Hox/Gtl2-Dio3 miRNA Axis

research Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis

January 2025 in “Frontiers in Cell and Developmental Biology”

Hox proteins help maintain keratinocyte identity by regulating miRNA expression.

research Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

2 citations , April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.

research Faculty Opinions recommendation of Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.

June 2013 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A substance called FGF9 from certain immune cells can trigger new hair growth during wound healing in mice, but humans may not have the same response due to fewer of these cells.

research Expression of type I hair keratins in follicular tumours

26 citations , May 2001 in “British Journal of Dermatology”

Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

research Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer

December 2024 in “European journal of medical research”

research Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations

30 citations , January 2021 in “Journal of Clinical Immunology”

FOXN1 mutations can cause varying immune and physical issues, with severity influenced by gene activity and possibly other factors.

research Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome

1 citations , May 2022 in “International journal of molecular sciences”

Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.

research Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration

12 citations , October 2024 in “Cell”

Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

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