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Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

3α-androstanediol helps reduce age-related cognitive and mood declines in male rats, unlike testosterone.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.

Pregnancy increases certain GABA_A receptors in rat brains, influenced by steroid levels.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Finasteride can cause sexual problems and depression in young men.

Finasteride might affect memory by impacting cholinergic system.

Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.

Neurosteroids show promise for treating epilepsy and more research is needed.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Finasteride slows down motherly behavior in first-time pregnant rats.