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The study concludes that certain domains in Clostridium histolyticum enzymes are structurally unique, bind calcium to become more stable, and play distinct roles in breaking down collagen, with potential applications in medicine and drug delivery.

New mutations in hair keratin genes cause the rare hair disorder monilethrix.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

The discovery of 5α-reductase deficiency in guevedoces led to the development of important urologic medications.

A new mutation, Glu402Lys, in hair keratin is linked to variable symptoms of monilethrix.

Idiopathic hirsutism causes excessive hair growth in women, can be treated with medication and hair removal, but cannot be fully reversed.

High glycine–tyrosine keratin-associated proteins help make hair strong and maintain its shape.

Triple H syndrome exists and can vary in symptoms.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Scientists now better understand the genetics of hypohidrotic ectodermal dysplasia, leading to more accurate diagnoses and potential new treatments.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Hidradenitis suppurativa improves with antiandrogen therapy.

Nicastrin deficiency may cause skin cell damage and pigmentation disorders in humans, similar to effects seen in fish.

Targeting impaired Nrf2 signaling might help treat hidradenitis suppurativa early on.

Finasteride reduces Hidradenitis Suppurativa flare-ups in children and teens, but long-term safety is unknown.

Cis-UCA can form new compounds without enzymes, and sulphide donors reduce its UVB-induced toxicity in skin cells.

Cinacalcet may help treat hereditary vitamin D resistant rickets safely.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Reduced matriptase activity causes skin and hair issues in both humans and mice.

Mesenchymal stem cells in people with Hidradenitis Suppurativa are more inflammatory, possibly contributing to the disease.

A specific gene mutation is linked to a hereditary form of dystonia that responds well to certain medications.

Eating foods with sulfhydryl may worsen pemphigus vulgaris.

Finasteride is an effective and well-tolerated treatment for hirsutism.

TMPRSS6 is crucial for controlling hepcidin and normal iron absorption.

Vitamin C was found to effectively treat prickly heat in children.

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

HLD10 can include increased body hair and Mongolian spots.

Blocking CXCR4 may help treat hidradenitis suppurativa.