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Lichen Planopilaris and Frontal Fibrosing Alopecia: Correlation of Clinical and Dermoscopic Findings with the Degree of Inflammation in Histopathological Examination

research Líquen plano pilar e alopecia frontal fibrosante: correlação dos achados clínicos e dermatoscópicos com o grau de inflamação do exame histopatológico

August 2022

Clinical signs don't match inflammation levels in lichen planopilaris and frontal fibrosing alopecia.

research Updates In The Pathogenesis Of Alopecia Areata

April 2021 in “Sohag Medical Journal”

Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.

Alopecia Areata Susceptibility Variant Identified by MHC Risk Haplotype Sequencing Reproduces Symptomatic Patched Hair Loss in Mice

research Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

A gene variant causes patched hair loss in mice, similar to alopecia areata in humans.

research Measuring the impact on quality of life of infants with atopic dermatitis in a dedicated clinic

February 2009 in “Journal of The American Academy of Dermatology”

Atopic dermatitis significantly lowers the quality of life for infants and their families.

research Cutaneous signals of immune system disease

May 1991 in “Current problems in dermatology”

Skin issues can indicate immune system problems.

research Weakly supervised learning of biomedical information extraction from curated data

232 citations , January 2016 in “BMC Bioinformatics”

The method can effectively extract biomedical information without needing expert annotation, performing better than previous models.

research Dermatologic Changes Associated With Interleukin 2 Administration

123 citations , September 1987 in “JAMA”

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

Epidemiology, Management, and the Associated Burden of Mental Health Illness, Atopic and Autoimmune Conditions, and Common Infections in Alopecia Areata: Protocol for an Observational Study Series

research Epidemiology, management and the associated burden of mental health illness, atopic and autoimmune conditions, and common infections in alopecia areata: protocol for an observational study series

11 citations , November 2021 in “BMJ Open”

People with alopecia areata have higher rates of mental health issues, autoimmune diseases, and infections.

research Prolonged Drug-Induced Hypersensitivity Syndrome/DRESS With Alopecia Areata and Autoimmune Thyroiditis

2 citations , August 2022 in “Federal Practitioner”

A severe medication reaction required long treatment and led to hair loss and thyroid issues.

research Effect of immunosuppressive ppiase inhibitors, cyclosporin A, FK506, ascomycin and rapamycin on hair growth initiation

August 1994 in “Journal of dermatological science”

Cyclosporin A and FK506 can start new hair growth in mice, but ascomycin and rapamycin cannot.

research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

474 citations , January 2012 in “Chemistry & biology”

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

research Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata

222 citations , September 2016 in “JCI insight”

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations , February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

research Drug-Induced Skin, Nail and Hair Disorders

114 citations , January 2007 in “Drug Safety”

Some drugs can cause skin, nail, and hair problems, which are important for healthcare professionals to recognize and report.

research Interferon in the treatment of cutaneous T-cell lymphoma

107 citations , December 2003 in “Dermatologic Therapy”

Interferon, especially alfa interferon, is an effective treatment for cutaneous T-cell lymphoma with manageable side effects.

Pityrosporum Species as a Cause of Allergy and Infection

research Pityrosporumi> species as a cause of allergy and infection

89 citations , May 1999 in “Allergy”

The yeast Pityrosporum ovale can cause skin allergies and infections, and antifungal treatments like ketoconazole are effective against it.

research Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies
82 citations , March 2016 in “Autoimmunity reviews”

Animal models have helped understand hair loss from alopecia areata and find new treatments.

research MENSTRUAL DISORDERS IN ADOLESCENTS
75 citations , June 1999 in “Pediatric Clinics of North America”

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts
68 citations , September 2018 in “International Journal of Molecular Sciences”

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

research Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study
66 citations , December 2018 in “Dermatology”

Both ruxolitinib and tofacitinib are effective and safe for treating severe alopecia areata, but relapses are common.

research Interventions for nail psoriasis
65 citations , January 2013 in “Cochrane library”

Some systemic treatments work for nail psoriasis but can have serious side effects.

research CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata
64 citations , July 2016 in “Journal of Immunology”

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

research Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures
61 citations , September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

research Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
59 citations , June 2022 in “Frontiers in medicine”

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

research Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations
58 citations , June 2018 in “Scientific reports”

Researchers found 15 new genetic links to skin traits in Japanese women.

research Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms
52 citations , September 2018 in “International Journal of Molecular Sciences”

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

research The spectrum of inflammatory skin disease following jejuno-ileal bypass for morbid obesity
51 citations , October 1981 in “British Journal of Dermatology”

Some patients developed skin inflammation after obesity surgery, and a medication called dapsone helped treat it.

research IL-15 in T-Cell Responses and Immunopathogenesis
48 citations , January 2024 in “Immune Network”

IL-15 is key for T cell function and could help improve treatments for immune-related diseases.

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