research The Role of Histone Demethylases in Disease
Histone demethylases play a key role in the development of many diseases and may be targets for treatment.
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research Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota
Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.
research Skin toxicity of anti‐cancer therapy
Anti-cancer treatments can cause reversible hair loss, skin sensitivity, pigmentation changes, nail damage, and skin reactions, with a need for more research on managing these side effects.
research Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role
Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.
research Dihydrotestosterone induces arterial stiffening in female mice
Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.
research 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis
Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.
research Redefining hormone resistance in prostate cancer
The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.
research Apocrine sweat gland obstruction by antiperspirants allowing transdermal absorption of cutaneous generated hormones and pheromones as a link to the observed incidence rates of breast and prostate cancer in the 20th century
The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.
research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance
Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.
research Priorities for efficacy trials of gender-affirming hormone therapy with estrogen: collaborative design and results of a community survey
Future hormone therapy trials should match the diverse needs and priorities of the gender-diverse community.
research Rooster feathering, androgenic alopecia, and hormone-dependent tumor growth: What is in common?
Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.
research Low sex-hormone binding globulin levels in young women with diffuse hair loss
Young women with diffuse hair loss may have low SHBG levels, which could lead to more active testosterone and contribute to their hair loss.
research Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies
Hormones and genes affect hair growth and male baldness.
research The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia
Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.
research Cutaneous drug reactions
Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.
research Liposome-based drug delivery systems for skin wound healing: a promising drug delivery strategy
Liposome-based systems improve skin wound healing effectively.
research Role of liposomal drug-delivery system in cosmetics
Liposomes improve the delivery and effectiveness of cosmetic ingredients but face challenges like cost and stability.
research Liposomal systems as drug delivery vehicles for dermal and transdermal applications
Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.
research Sex hormones modulate pathogenic processes in experimental traumatic brain injury
Sex hormones affect brain injury differently in males and females.
research Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?
Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
research Dissolving microneedles: an advanced approach for transdermal drug delivery
Dissolving microneedles offer efficient, minimally invasive drug delivery through the skin.
research Ayurveda & Bioactives as Adjuvant for Dna Modulation in Cancer Treatment & Adverse Drug Reaction [ADR] – A Glimpse of Traditional Indian Nanotechnology
Ayurvedic herbs may reduce side effects and improve effectiveness of cancer treatments.
research Drug Armamentarium for alopecia areata
No cure exists for alopecia areata, and treatments are personalized.
research Sertolioma in a Canadian Husky: Relationship between Tumor, Hormones, Neurons and Skin
Removing a testicular tumor in a dog reduced its aggressive behavior and skin problems.
research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells
Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.
research Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane
Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.
research An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess
Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.
research Drug repositioning using in silico compound profiling
Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.
research Drug interactions between herbal medicines and oral contraceptives
Herbal medicines can reduce the effectiveness of birth control pills.
research Social Interest Data as a Proxy for Off-Label Performance-Enhancing Drug Use: Implications and Clinical Considerations
Clinicians should use social and prescription data to track trends in performance-enhancing drug use.