October 2024 in “Journal of the Endocrine Society” Hirsutism in young girls can have various causes beyond PCOS, so diagnoses should be reconsidered if treatments don't work.
February 2026 in “Psychoneuroendocrinology” Hair cortisol concentration partly reflects HPA axis regulation but doesn't capture all its complexities.
August 2013 in “Annals of Translational Medicine” HPE may help treat osteoarthritis by promoting cartilage regeneration.
27 citations
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April 2007 in “European Journal of Pharmacology” Progesterone increases alcohol tolerance and withdrawal anxiety, while DHEAS prevents them.
January 2006 in “Basic & Clinical Medicine” Hair keratin doesn't significantly affect rat organ function but may help detect early rejection through blood changes.
54 citations
,
November 1995 in “The Journal of Clinical Endocrinology & Metabolism” Females with 5 alpha-reductase-2 deficiency have less body hair, no acne, normal fertility, and delayed menarche.
93 citations
,
June 2011 in “Journal of Neuroscience” p63 is essential for activating and differentiating stem cells in the nose's olfactory tissue.
237 citations
,
December 2001 in “Urology” Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
24 citations
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July 2016 in “Steroids” Progesterone and testosterone protect brain cells from damage through specific pathways.
15 citations
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September 2014 in “PloS one” The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.
12 citations
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May 2016 in “Experimental Dermatology” A new skin model from hair follicles is a safer, simpler alternative for skin tests.
13 citations
,
August 1985 in “The Journal of Dermatology” HKN-2 antibody targets specific skin and hair cells, showing keratin complexity.
114 citations
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May 2001 in “Development” Overexpression of Hoxc13 in hair cells causes hair loss and skin issues.
April 2023 in “Expert opinion on pharmacotherapy” Birth control pills and antiandrogens are the most effective medicines for excessive body hair in women, but combining them with other treatments and psychological support is best.
62 citations
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October 1999 in “Journal of Investigative Dermatology” New mutations in hair keratin genes can change hair structure and cause monilethrix, with nail issues more common in certain gene mutations.
28 citations
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March 2000 in “Obstetrics and gynecology clinics of North America” Hirsutism in teen girls is common, usually harmless, but can sometimes signal serious issues and is treatable.
12 citations
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April 1987 in “PubMed” Low-dose spironolactone is safe and effective for treating hirsutism.
49 citations
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June 1998 in “Journal of Endocrinological Investigation” Cyproterone acetate plus ethinyl estradiol is generally more effective in treating hirsutism, but consider side effects and patient characteristics.
November 2002 in “Hair transplant forum international” The IBHRS is now operational.
January 2026 in “Dermatologic Therapy” Higher RBP4 levels are linked to severe alopecia areata, but genetic variant rs3758539 doesn't affect baricitinib response.
108 citations
,
April 2004 in “Medicinal Research Reviews” Steroid sulfatase inhibitors could help treat hormone-related disorders and cancers.
May 2008 in “10th European Congress of Endocrinology” April 2022 in “Dermatologic Therapy” Diode laser treatment works better for facial hirsutism in patients with normal hormone levels.
18 citations
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February 1992 in “Molecular Biology Reports” A specific type II hair keratin was identified and found in hair cortex and tongue cells.
39 citations
,
November 1978 in “Annals of internal medicine” Spironolactone may help reduce excessive hair growth in women with high male hormone levels.
56 citations
,
March 2003 in “Journal of Investigative Dermatology” 17β-estradiol can reduce inflammation in the skin.
50 citations
,
July 2018 in “Psychoneuroendocrinology” Hair cortisol can indicate long-term stress levels, but hair growth rate differences may affect accuracy.
113 citations
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April 1999 in “The Journal of Clinical Endocrinology and Metabolism” Cyproterone acetate-estrogen most effective for hirsutism, but consider side effects and patient needs.
32 citations
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October 2015 in “Frontiers in Cellular Neuroscience” DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.
November 2014 in “International Society of Hair Restoration Surgery”