25 citations
,
May 2020 in “EMBO reports” Calcium is important for stem cell function and maintenance, especially in blood and skin cells.
Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.
2 citations
,
January 2016 in “Experimental Dermatology” HS needs personalized treatment plans and more research.
29 citations
,
June 2017 in “Journal of Inherited Metabolic Disease” High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.
1 citations
,
January 2018 in “Methods in molecular biology” The research found ways to activate melanocyte stem cells for potential treatment of skin depigmentation conditions.
3 citations
,
May 2018 in “Experimental Dermatology” Young HS patients often have other physical and mental health issues, and research on HS covers a wide range of topics including genetics, triggers, treatments, and the need for more data.
480 citations
,
August 2014 in “Nature Biotechnology” Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
179 citations
,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
89 citations
,
January 2009 in “Advances in Clinical Chemistry” Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.
76 citations
,
July 2019 in “Cellular and Molecular Life Sciences” Stem cells are crucial for tissue growth, cancer treatment, and disease modeling, but challenges remain in clinical use.
18 citations
,
February 2022 in “Cell Death Discovery” ECM1-modified stem cells can effectively treat liver cirrhosis.
17 citations
,
November 2017 in “PLoS ONE” Transplanted bone marrow cells actively move, form clusters, and grow after transplantation.
3 citations
,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
March 2025 in “Medical & Clinical Research” Stem cell therapy can help regrow hair and increase hair density.
November 2018 in “Atlas of genetics and cytogenetics in oncology and haematology” WNT10B is linked to cancer development and affects survival and disease progression in various cancers.
January 2012 in “Else Kröner-Fresenius Symposia” Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.
19 citations
,
August 2018 in “JAMA dermatology” Mesenchymal stem cells in people with Hidradenitis Suppurativa are more inflammatory, possibly contributing to the disease.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.
August 2022 in “JAAD case reports” A woman with a long-term skin condition developed a serious skin cancer that led to her death.
48 citations
,
March 2020 in “Stem Cell Research & Therapy” Using a collagen sponge scaffold helps stem cells become more like skin cells.
Hair cortisol may help identify adrenal insufficiency in sickle cell disease patients.
April 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” Certain surgical methods are better than routine incision for hidradenitis suppurativa, topical clindamycin and acitretin are effective treatments, men with HS have a risk of skin cancer, HS patients are more likely to die from heart problems, and specific genetic markers are linked to treatment response.
26 citations
,
August 2009 in “Journal of Pediatric Gastroenterology and Nutrition” Hoyeraal-Hreidarsson syndrome in infants causes severe gastrointestinal issues.
1160 citations
,
November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
759 citations
,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
556 citations
,
September 2008 in “Genes & Development” Wnt signaling is vital for cell growth, development, and cancer research.
343 citations
,
December 2008 in “Endocrine Reviews” Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
333 citations
,
February 2010 in “Cell Stem Cell” Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.
316 citations
,
June 2017 in “Stem Cell Research & Therapy” Fat tissue-derived cells show promise for repairing body tissues, but more research and regulation are needed for safe use.
271 citations
,
May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.