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research Estrone Sulfate Source of Estrone and Estradiol Formation in Isolated Human Hair Roots: Identification of a Pathway Linked to Hair Growth Phase and Subject to Site-, Gender-, and Age-Related Modulations

11 citations , January 2014 in “The Journal of Clinical Endocrinology & Metabolism”

Estrogen formation in hair roots affects hair growth and varies by site, gender, and age.

research In vitro effects of testosterone, dihydrotestosterone and estradiol on cell growth of human hair bulb papilla cells and hair root sheath fibroblasts.

22 citations , July 1990 in “Acta Dermato Venereologica”

High levels of testosterone and dihydrotestosterone inhibit hair cell growth, while high levels of estradiol promote it.

research Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel

7 citations , July 2016 in “Journal of Biomedical Materials Research Part A”

cGEL hydrogel improves melanin production in skin cells, making it a promising option for skin treatments.

research Keratins 1 and 10 or homologues as regular constituents of inner root sheath and cuticle cells in the human hair follicle.

44 citations , August 1990 in “PubMed”

Keratins K1 and K10 are found in the inner root sheath and cuticle of human hair follicles.

Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro

9 citations , March 1987 in “British Journal of Dermatology”

EGF and FGF can boost hair growth by speeding up cell growth.

Ultrastructural Immunolocalization of Involucrin in the Medulla and Inner Root Sheath of Human Hair

research Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair

7 citations , December 2011 in “Annals of anatomy”

Involucrin helps strengthen the inner parts of human hair.

research 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo

1 citations , July 2024 in “Journal of Investigative Dermatology”

MPZL3 protein affects hair growth cycles and could help manage hair loss.

research Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans

38 citations , October 2001 in “British Journal of Dermatology”

Keratin K6irs is a marker for the inner root sheath of hair follicles in mice and humans.

research Simultaneous Typing of Erythrocyte Acid Phosphatase, Adenylate Kinase and Adenosine Deaminase in Human Hair Root Sheaths

1 citations , September 1986 in “Journal of the Forensic Science Society”

Hair root sheaths can be used to accurately analyze genetic markers.

research Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells

62 citations , June 1993 in “Archives of Dermatological Research”

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research Improved isolation of outer root sheath cells from human hair follicles and their proliferation behavior under serum-free condition

13 citations , February 2007 in “Biotechnology and Bioprocess Engineering”

research Epidermis reconstructed from the outer root sheath of human hair follicle on de-epidermized dermis. Effect of retinoic acid

August 1993 in “Journal of Dermatological Science”

research Effect of minoxidil-sulfate on cultured human hair papilla cells (PCs) and root sheath fibroblasts(RSFs)

September 1992 in “Journal of Dermatological Science”

research 597 Outer root sheath is able to synthesise glycogen from lactate-investigating glycogen metabolism in human hair follicles

7 citations , September 2019 in “Journal of Investigative Dermatology”

research 083 The effect of topical hair growth promoters on internal calcium of human outer root sheath cells(ORSCs)

June 1996 in “Journal of Dermatological Science”

research Effects of testosterone, dihydrotestosterone and estradiol on growth of human hair outer root sheath keratinocytes in vitro

9 citations , October 1991 in “Archives of Dermatological Research”

Testosterone, DHT, and estradiol significantly affect hair cell growth.

Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro

60 citations , May 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

41 citations , January 2001 in “Journal of Investigative Dermatology”

research Immunohistochemical analysis of tissue remodelling during the anagen—catagen transition of the human hair follicle

23 citations , July 1997 in “British Journal of Dermatology”

The inner root sheath is vital for hair follicle stability during growth changes.

Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

research Wnt/β-catenin and ERK pathway activation: The possible mechanism of various light-emitting diode light regulates the proliferation of human outer root sheath cells

May 2017 in “Journal of The American Academy of Dermatology”

LED light helps human hair root cells grow and move by activating certain cell pathways.

research Restoration of hair-inductive activity of cultured human follicular keratinocytes by co-culturing with dermal papilla cells

14 citations , September 2018 in “Biochemical and Biophysical Research Communications”

Growing hair cells with dermal cells can potentially treat hair loss.

research Enrichment of human hair follicle stem cells by adhering to typeIVcollagen

January 2006

Human hair follicle stem cells can be enriched by sticking to type IV collagen.

research Human hair keratin network and curvature

85 citations , October 2007 in “International Journal of Dermatology”

Curly hair shape is due to uneven growth patterns in the hair follicle.

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