January 2026 in “Clinical Chemistry and Laboratory Medicine (CCLM)” The procedure accurately measures 5-alpha-dihydrotestosterone in blood, useful for standard tests.
188 citations
,
January 2022 in “PubMed” Advancements in understanding, diagnosing, and managing congenital adrenal hyperplasia have improved treatment and long-term outcomes.
180 citations
,
June 2004 in “Journal of Pharmacology and Experimental Therapeutics” Progesterone's seizure-reducing effects are mainly due to allopregnanolone, not progesterone receptors.
136 citations
,
January 2004 in “Neuroscience” Testosterone increases seizure risk through its conversion to specific neurosteroids.
87 citations
,
September 2006 in “Clinical Cancer Research” Protein Kinase C shows promise for cancer treatment, but more research is needed to develop effective inhibitors.
64 citations
,
June 1995 in “Steroids” Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.
48 citations
,
February 1999 in “PubMed” Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.
46 citations
,
August 2006 in “PubMed” A genetic defect causes males in some Mediterranean populations to be born with ambiguous genitalia and develop male traits at puberty.
32 citations
,
July 2003 in “Histochemistry and Cell Biology” 24 citations
,
February 2012 in “Prostate cancer and prostatic diseases” 5α-reductase inhibitors help shrink the prostate, improve urinary symptoms, and may reduce prostate cancer risk.
17 citations
,
January 2020 in “The World Journal of Men's Health” Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.
17 citations
,
August 2010 in “International Journal of Cosmetic Science” Orthosiphon stamineus leaf extract reduces oily skin and improves complexion better than zinc gluconate.
12 citations
,
September 2015 in “Drug Design Development and Therapy” AD198 is more effective than doxorubicin in stopping certain dog cancer cells.
8 citations
,
July 2021 in “F1000Research” Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.
7 citations
,
February 2020 in “Analytical and Bioanalytical Chemistry”
7 citations
,
December 2019 in “Pharmaceutics” Taking Dutasteride with Ketoconazole can increase Dutasteride's effects and side effects.
6 citations
,
October 2014 in “Experimental Dermatology” Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.
5 citations
,
November 2015 in “Journal of Enzyme Inhibition and Medicinal Chemistry” Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.
4 citations
,
December 2017 in “PubMed” Minoxidil may help treat hair loss by reducing the activity of a specific enzyme linked to baldness.
3 citations
,
January 2022 in “Precision medicine and clinical omics” Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.
3 citations
,
December 2021 in “Frontiers in Pharmacology” Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.
3 citations
,
May 2020 in “Journal of The Korean Medical Association” Minoxidil and finasteride are effective for treating hair loss, with dutasteride showing potential but with side effects.
3 citations
,
March 2016 in “Medicinal Chemistry Research” Scientists found out the structure of a human enzyme linked to prostate cancer and hair loss, which could help in designing drugs.
3 citations
,
December 2024 in “Biomolecules & Therapeutics” Tanshinone compounds can help prevent hair loss caused by testosterone.
2 citations
,
September 2025 in “Frontiers in Endocrinology” SARMs show promise but need more evidence to prove they're better than traditional androgens.
ACA from Alpinia galanga may prevent testosterone-related hair loss.
January 2025 in “Case Reports in Genetics” A rare gene variant causes sexual development issues in siblings, needing personalized treatment.
October 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” Rodent models of PCOS show some similar and some different lipid changes compared to humans.
June 2024 in “Reviews on Recent Clinical Trials” Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.
April 2024 in “JCEM case reports” A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.