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Expression Patterns of Glial Cell Line-Derived Neurotrophic Factor, Neurturin, Their Cognate Receptors GFRα-1, GFRα-2, and Common Signal Transduction Element c-Ret in Human Skin Hair Follicles

research Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles

18 citations , January 2008 in “Journal of The American Academy of Dermatology”

Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.

research A phosphoinositide-mediated switch of GET pathway receptor dimerization in Arabidopsis

October 2025 in “Proceedings of the National Academy of Sciences”

Phospholipids help plant proteins move by regulating receptor interactions.

research 0874 TGF-β signaling-mediated wound healing is required for hair follicle neogenesis

July 2025 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for hair follicle regeneration during wound healing.

research Effects of the PI3K/Akt signaling pathway on the hair inductivity of human dermal papilla cells in hair beads

12 citations , April 2022 in “Journal of Bioscience and Bioengineering”

Activating the PI3K/Akt pathway improves hair growth by human dermal papilla cells in hair beads.

research Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism^¶

3 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may promote skin cancer development after UV exposure by affecting nearby cells.

research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

research Targeting cardiac hypertrophy through a nuclear co‐repressor

3 citations , October 2019 in “EMBO molecular medicine”

Targeting NCoR1 can help treat heart enlargement and dysfunction.

research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

54 citations , June 2008 in “Planta Medica”

Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.

research Study on the regulatory effect of Panax notoginseng saponins combined with bone mesenchymal stem cell transplantation on IRAK1/TRAF6-NF-κB pathway in patients with diabetic cutaneous ulcers

10 citations , January 2023 in “Journal of Orthopaedic Surgery and Research”

Panax notoginseng saponins with stem cells improve healing and reduce inflammation in diabetic ulcers.

research 0866 Role of transcriptional elongation in dermal fat development

July 2025 in “Journal of Investigative Dermatology”

Nelfb is essential for dermal fat development and survival.

research Placental mRNA Expression of Neurokinin B Is Increased in PCOS Pregnancies with Female Offspring

February 2024 in “Biomedicines”

Pregnant women with PCOS have higher levels of Neurokinin B in the placenta, especially with female babies.

research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

26 citations , June 2003 in “PubMed”

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

research Tissue and Circulating MicroRNA Co-expression Analysis Shows Potential Involvement of miRNAs in the Pathobiology of Frontal Fibrosing Alopecia

8 citations , July 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain microRNAs might help identify and understand Frontal Fibrosing Alopecia.

research The TNFRSF1B Connection: Implications for Androgenetic Alopecia Pathogenesis and Treatment

May 2025 in “The FASEB Journal”

Targeting the TNFRSF1B gene may help treat hair loss.

research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

research The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin‐1 (PN‐1) inhibition

14 citations , August 2014 in “The FASEB Journal”

CAP1/Prss8 does not activate PAR2 or inhibit PN-1.

Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

research 1322 Molecular profiling of frontal fibrosing alopecia (FFA) reveals TH1 and JAK-STAT up-regulation with no suppression of hair keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

research GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration

2 citations , January 2022 in “Experimental Dermatology”

GDNF signaling helps in hair growth and skin healing after a wound.

research RNase L represses hair follicle regeneration through altered innate immune signaling

February 2025 in “Journal of Clinical Investigation”

RNase L hinders hair growth by altering immune signals.

research Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway

8 citations , June 2023 in “Acta Biochimica et Biophysica Sinica”

rRSPO1 protein boosts hair growth by activating a key signaling pathway.

research 1312 Nrf2 activation enhances the healing of cutaneous wounds through the activation of hair follicle stem cells

April 2018 in “Journal of Investigative Dermatology”

Activating Nrf2 helps wounds heal faster by increasing hair follicle stem cells.

research Sorafenib stimulates human skin type mast cell degranulation and maturation

7 citations , August 2017 in “Journal of dermatological science”

Sorafenib causes skin reactions by increasing the number and activity of skin mast cells.

research An effective range of polydeoxyribonucleotides is critical for wound healing quality

22 citations , October 2018 in “Molecular Medicine Reports”

Classic PDRN improves wound healing quality by enhancing cell migration.

research Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice

October 2014 in “Cancer research”

Blocking mTORC1 reduces skin tumor growth in mice.

A New Way to Restore Tumor Suppressor Function

research A new way to restore tumour suppressor function

August 2013 in “Nature Reviews Drug Discovery”

New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.

MiR-27a Targeting PIK3R3 Regulates the Proliferation and Apoptosis of Sheep Hair Follicle Stem Cells

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