April 2018 in “Journal of Investigative Dermatology” Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.
April 2018 in “Journal of Investigative Dermatology” Nicotinic acid reduces excessive oil production in skin cells by activating a specific receptor, which could help treat acne.
April 2018 in “Journal of Investigative Dermatology” The role of γδT-cells in causing alopecia areata remains unclear.
April 2018 in “Journal of Investigative Dermatology” Mint water extract boosts protective enzymes in skin cells.
April 2018 in “Journal of Investigative Dermatology” Claudin-1 and Claudin-3 are crucial for keeping hair follicle structure and preventing a type of hair loss called telogen effluvium.
April 2018 in “Journal of Investigative Dermatology”
21 citations
,
June 2016 in “Reproductive Sciences” Women with PCOS, especially those overweight, have higher levels of IL-18 in their endometrium, which may affect fertility.
171 citations
,
July 2007 in “Journal of Investigative Dermatology” A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
100 citations
,
September 1999 in “British Journal of Dermatology” The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.
53 citations
,
March 2014 in “Growth Hormone & IGF Research” IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.
41 citations
,
October 2011 in “Journal of Dermatology” Finasteride 1 mg effectively and safely increases hair growth in Japanese men with hair loss.
37 citations
,
March 2006 in “Regulatory Peptides” Mice skin has components that could help with hair growth and might be used for diabetes treatment.
20 citations
,
October 2008 in “European journal of endocrinology” Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.
20 citations
,
December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Blocking IL-12/IL-23 does not help with hair loss in alopecia areata for mice or humans.
15 citations
,
August 2020 in “American Journal of Pathology” Insulin helps heal corneal wounds and nerves in diabetic mice by activating the Wnt signaling pathway.
9 citations
,
September 2017 in “Nanoscale Research Letters” Graphene oxide helps deliver a skin healing agent over time, improving skin and hair follicle regeneration.
7 citations
,
April 2021 in “Dermatology and Therapy” H-1 antihistamines may help with various skin conditions, but more research is needed to confirm their effectiveness.
7 citations
,
September 2020 in “Frontiers in Cell and Developmental Biology” IL-36α helps grow new hair follicles and speeds up wound healing.
2 citations
,
May 2022 in “Research Square (Research Square)” KGF-1 135 is a stable and effective alternative for treating oral mucositis.
2 citations
,
September 2020 in “Journal of Education Health and Sport” Higher IL-15 levels are linked to more severe hair loss in alopecia areata.
1 citations
,
January 2020 in “Benha Journal of Applied Sciences” Certain gene variations may increase the risk and severity of alopecia areata.
March 2026 in “Medeniyet Medical Journal” EH-MSCs may help treat hair loss by boosting regeneration and reducing inflammation.
December 2025 in “Babcock University Medical Journal” CD27 and IL-35 can help diagnose alopecia areata linked to bacterial infections.
December 2025 in “Naunyn-Schmiedeberg s Archives of Pharmacology” Agomelatine may help reduce benign prostatic hyperplasia by blocking certain inflammatory pathways.
August 2023 in “Research Square (Research Square)” Two microRNAs affect hair follicle development in sheep by targeting specific genes.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
January 2023 in “International Journal of Zoological Investigations” Certain genetic variations in IL-16 may increase the risk of alopecia areata.
January 2022 in “The Egyptian Journal of Hospital Medicine” Higher IL-21 levels may help predict alopecia areata activity.
The document recommends a multidisciplinary approach and experience sharing to advance facial feminization surgery as a medical field.