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Physicochemical Properties of pH-Sensitive Hydrogels Based on Hydroxyethyl Cellulose–Hyaluronic Acid for Transdermal Delivery Systems for Skin Lesions

research Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose–hyaluronic acid and for applications as transdermal delivery systems for skin lesions

118 citations , May 2015 in “European journal of pharmaceutics and biopharmaceutics”

The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.

research THBS4 promotes hair regeneration by inducing dermal mechanical niche adaptation

June 2026 in “Research Square”

The study highlights the crucial role of THBS4 in hair regeneration by modulating the mechanical properties of the dermal niche, which reduces matrix stiffness and enhances interactions between the epidermis and dermis. This process activates hair follicle stem cells (HFSCs) and accelerates the transition from the telogen to anagen phase, promoting hair growth. THBS4 upregulation in dermal fibroblasts activates signaling pathways involving ITGB1, EGR1, and HMGCR, facilitating HFSC proliferation. Experiments with mice and organoids showed that THBS4 treatment significantly enhances hair regeneration, suggesting its potential as a therapeutic target for hair loss treatments. Further research is needed to explore the detailed mechanisms of THBS4 in extracellular matrix assembly and metabolic reprogramming.

research Targeted Inactivation of Gh/Tissue Transglutaminase II

288 citations , January 2001 in “Journal of Biological Chemistry”

Tgm2 helps stabilize dying cells and aids fibroblast attachment to the extracellular matrix.

research TBG096 stimulates hair regeneration through IGF-1R-mediated angiogenesis

January 2026 in “Biochemical Pharmacology”

Helminth TGF-β Mimic, TGM, Increases Leukocyte Migration and Activation While Also Enhancing Cutaneous Wound Healing and Tissue Regeneration

research Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration.

May 2022 in “Journal of Immunology”

A parasite molecule can speed up skin healing and reduce scarring.

research Transglutaminase-3, an esophageal cancer-related gene

32 citations , January 2000 in “International Journal of Cancer”

Transglutaminase-3 is often reduced in esophageal cancer.

research Human Epidermal Transglutaminase

53 citations , June 1983 in “Journal of Investigative Dermatology”

The enzyme is crucial for skin cell development and can be activated without proteolytic activation.

research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

30 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

TGase 3 helps build hair structure by forming strong bonds between proteins.

research A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activation

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A parasite-derived molecule speeds up skin healing and affects immune cell behavior without increasing scarring.

research Identification of a preferred substrate peptide for transglutaminase 3 and detection of in situ activity in skin and hair follicles

35 citations , July 2010 in “The FEBS journal”

The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations , August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations , February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

research Tebentafusp-tebn (Kimmtra®)

March 2022 in “Oncology Times”

Tebentafusp-tebn improves survival rates in uveal melanoma patients but has common side effects like rash and fatigue.

research Differential transcriptome study on the damage of testicular tissues caused by chronic infection of T. gondii in mice

2 citations , June 2024 in “Parasites & Vectors”

Chronic T. gondii infection may harm male fertility.

research Intermittent Use of Testosterone Inactivating Pharmaceuticals Using Finasteride Prolongs the Time Off Period

32 citations , April 2006 in “The Journal of Urology”

Using finasteride with TIP extends time off period for prostate cancer patients.

research Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease

60 citations , September 2023 in “Science”

BTNL proteins help control inflammatory bowel disease by maintaining specific immune cells.

research Transglutaminase 5 Expression in Human Hair Follicle

28 citations , August 2005 in “Journal of Investigative Dermatology”

TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.

Simultaneous Effects of Tocopheryl Polyethylene Glycol Succinate on Local Hair Growth Promotion and Systemic Absorption of Topically Applied Minoxidil in a Mouse Model

research Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model

18 citations , October 2005 in “International Journal of Pharmaceutics”

Adding a small amount of TPGS to minoxidil can help hair growth, but too much TPGS reduces this effect and increases minoxidil in the blood.

research Gingerol ameliorates chronic graft-versus-host disease by regulating treg/Th17 transdifferenciation

November 2025 in “Blood”

Gingerol may help treat chronic graft-versus-host disease by improving immune cell balance.

research Group Treatment for Trichotillomania: Behavior Therapy Versus Supportive Therapy

69 citations , August 2006 in “Behavior Therapy”

Group behavior therapy reduces hair-pulling symptoms more than supportive therapy but has limited long-term effectiveness.

research Sacituzumab Govitecan-Hziy (Trodelvy™)

3 citations , April 2021 in “Oncology Times”

Trodelvy™ helped some patients with advanced breast cancer, but had side effects.

Demethylation of ITGAV Accelerates Osteogenic Differentiation in a Blast-Induced Heterotopic Ossification In Vitro Cell Culture Model

research Demethylation of ITGAV accelerates osteogenic differentiation in a blast-induced heterotopic ossification in vitro cell culture model

11 citations , December 2018 in “Bone”

Removing a methyl group from the ITGAV gene speeds up bone formation in a specific type of bone disease model.

research Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model.

January 2005 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)”

0.5% TPGS boosts hair growth with minoxidil, but 2% TPGS increases minoxidil absorption.

research Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

43 citations , January 2016 in “Oxidative medicine and cellular longevity”

THSG from a Chinese plant helps with aging and related diseases.

Chemical Reactions in Curing Treatment for Permanent Hair Straightening Using Thioglycolic and Dithioglycolic Acids

research Chemical Reactions Occurring in Curing Treatment for Permanent Hair Straightening Using Thioglycolic and Dithioglycolic Acids

3 citations , January 2009 in “Sen'i Gakkaishi”

Using both TGA and DTDG in hair straightening reduces hair damage compared to using TGA alone.