24 citations
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March 2016 in “Journal of Investigative Dermatology” TIP39 and PTH2R help control calcium levels and skin cell development.
191 citations
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May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
September 2004 in “Experimental dermatology” Melatonin directly affects mouse hair follicles and may influence hair growth.
441 citations
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May 2008 in “British Journal of Pharmacology” Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.
349 citations
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January 2005 in “The FASEB journal” Human skin can make serotonin and melatonin, which help protect and maintain it.
252 citations
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April 2009 in “Seminars in Cell & Developmental Biology” The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
219 citations
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January 2006 in “Drug Metabolism Reviews” DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.
174 citations
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April 2005 in “The American journal of pathology (Print)” Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.
150 citations
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April 2013 in “Dermato-endocrinology” Estrogen therapy can reduce skin aging but has cancer risks.
150 citations
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August 1992 in “Genes & Development” TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.
148 citations
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December 2018 in “Journal of autoimmunity” Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.
139 citations
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August 2018 in “Development” The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.
134 citations
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July 2020 in “Experimental dermatology” Hair follicles are normally protected from the immune system, but when this protection fails, it can cause hair loss in alopecia areata.
125 citations
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September 2019 in “Journal of Clinical Immunology” Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.
111 citations
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June 2002 in “The EMBO Journal” Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.
110 citations
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July 2017 in “Immunology” Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.
76 citations
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April 2013 in “PLoS ONE” Chronic stress can cause hair loss by increasing oxidative stress, but antioxidants may help.
67 citations
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May 2018 in “Journal of Ginseng Research” Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.
64 citations
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July 2016 in “Journal of Immunology” Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.
50 citations
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January 2016 in “The FEBS journal” RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
47 citations
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September 2023 in “Pharmacological Reports” Vitamins A, B3, C, D, and E can improve skin health and immunity.
45 citations
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December 2014 in “Journal of the European Academy of Dermatology and Venereology” Plasmacytoid dendritic cells are a key factor in causing hair loss in alopecia areata and could help differentiate it from other hair loss conditions.
44 citations
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November 2022 in “Frontiers in Immunology” TLR-targeted therapies show promise in cancer treatment by helping destroy tumors.
44 citations
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November 1998 in “Australasian Journal of Dermatology” Accurate diagnosis is key for treating different kinds of hair loss, and immune response variations may affect the condition and treatment results.
41 citations
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July 2019 in “Clinical Cosmetic and Investigational Dermatology” The skin's immune system helps it regenerate and fight infections.
40 citations
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August 2022 in “Frontiers in immunology” Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.
40 citations
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March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
38 citations
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January 2016 in “Cell Death and Disease” The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.
32 citations
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January 2017 in “PLoS ONE” Adiponectin boosts lipid production in skin cells, potentially helping treat skin conditions with low sebum.
31 citations
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April 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Androgens cause oil-producing skin cells with androgen receptors to mature and produce more oil.