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GlossaryImmune-Related Pathways

series of immune system interactions responding to threats

Immune-related pathways are the series of interactions and processes within the body that involve the immune system's response to threats like infections, diseases, or even malfunctioning cells. These pathways include the activation of immune cells, the release of signaling molecules, and the coordination of various immune responses to protect the body. Understanding these pathways is crucial for developing treatments for autoimmune diseases, where the immune system mistakenly attacks the body's own tissues, such as in alopecia areata.

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research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

September 2023 in “Medicine”

The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.

research Synaptic processes and immune-related pathways implicated in Tourette syndrome

29 citations , January 2021 in “Translational Psychiatry”

The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.

research Synaptic processes and immune-related pathways implicated in Tourette Syndrome

1 citations , April 2020 in “medRxiv (Cold Spring Harbor Laboratory)”

The study found that Tourette Syndrome may be linked to certain immune system processes and synaptic signaling.

research Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

March 2023 in “Research Square (Research Square)”

Immune changes and specific genes contribute to male hair loss.

Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency

research Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

64 citations , August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

A deficiency in the TTC7A gene causes immune problems, gut issues, and hair loss.

research Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis

November 2022 in “Annals of Translational Medicine”

Immune activities and specific genes are important in male pattern baldness.

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

January 2023 in “Research Square (Research Square)”

IGF2BP3 gene is up-regulated in keloid patients, suggesting potential targets for treatment.

research
The regenerative potential of skin and the immune system

41 citations , July 2019 in “Clinical Cosmetic and Investigational Dermatology”

The skin's immune system helps it regenerate and fight infections.

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.

research Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens

July 2025

Scalp psoriasis inflammation is mainly caused by bacteria-related triggers.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

Biological Insights from Self-Perceived Facial Aging Data of the UK Biobank Participants

research Biological insights from self-perceived facial aging data of the UKBB participants

2 citations , September 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

Self-perceived facial aging is linked to skin pigmentation, immune system, hair loss in men, and genes related to the skin's structure.

research Aberrant B cell and cytotoxic T cell activation in female pattern hair loss: a pilot comparative clinico-transcriptomic study

December 2025 in “Journal of Investigative Dermatology”

Immune system issues may contribute to female pattern hair loss.

Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia

research Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia

May 2025 in “Journal of Inflammation Research”

Natural killer and CD8+ T cells play a key role in hair loss in androgenetic alopecia.

research Endocrinology

April 2023 in “Clinical Chemistry and Laboratory Medicine”

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

June 2021 in “Research Square (Research Square)”

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.

Alopecia Areata: Overview and Insights from January 2018

research Alopecia areata

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Parsing patterns: Emerging roles of tissue self-organization in health and disease

22 citations , June 2024 in “Cell”

Understanding tissue self-organization can improve treatments for diseases and advance regenerative medicine.

research Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction

September 2025 in “International Journal of Molecular Sciences”

Unmodified fullerene C60 promotes hair growth and may help treat hair loss.

research MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

1 citations , December 2023 in “International journal of molecular sciences”

miR-199a-3p controls hair growth and is linked to alopecia areata.

Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)

November 2021 in “Research Square (Research Square)”

3D spheroid cultures of human hair follicle cells are better for hair growth research than 2D cultures, and they provide new insights into how hair growth treatments like minoxidil and TCQA work.

research Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

13 citations , October 2019 in “Journal of lasers in medical sciences”

CO2 laser treatment for aging skin significantly changes immune system-related genes.

research JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis

223 citations , September 2018 in “Rheumatology”

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

The immune processes causing VKH and vitiligo are similar in dogs and humans.

research Identification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel

4 citations , May 2020 in “PLOS ONE”

Ingenol mebutate gel changes gene expression related to skin development and immune response in actinic keratosis.

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

2 citations , August 2020 in “Scientific reports”

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

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Related Terms

Research

research Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia

research Synaptic processes and immune-related pathways implicated in Tourette syndrome

research Synaptic processes and immune-related pathways implicated in Tourette Syndrome

research Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia

research Immune deficiency–related enteropathy-lymphocytopenia-alopecia syndrome results from tetratricopeptide repeat domain 7A deficiency

research Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis

research Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model

research
The regenerative potential of skin and the immune system

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

research Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

research Biological insights from self-perceived facial aging data of the UKBB participants

research Aberrant B cell and cytotoxic T cell activation in female pattern hair loss: a pilot comparative clinico-transcriptomic study

research Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia

research Endocrinology

research Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

research Alopecia areata

research Parsing patterns: Emerging roles of tissue self-organization in health and disease

research Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction

research MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)

research Assessment of Cytokine-Mediated Signaling Pathway Dysregulation in Arm Skin After CO2 Laser Therapy

research JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

research Identification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

research Characterization of novel TMEM173 mutation with additive IFIH1 risk allele

research Proteins observed in scalp hair from preschool children

research Regulatory pathways implicated in male androgenetic alopecia pathogenesis