research Foxp3 Post-translational Modifications and Treg Suppressive Activity
Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.
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480-510 / 1000+ results research MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression
MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.
research 0085 Th1/Th2 balance, IFN-γ–MHC-I axis, and regulatory T cells define therapeutic response endotypes in alopecia areata
research 0054 Treg-targeted therapies restrain disease in a murine model of alopecia areata
Enhancing Tregs can protect against alopecia areata.
research Topical immunomodulators in dermatology.
Topical immunomodulators are effective and safe for treating immune-related skin conditions.
research Regulatory T cells are required for normal and activin‐promoted wound repair in mice
Regulatory T cells are essential for normal and improved wound healing in mice.
research Immune modulation of hair follicle regeneration
Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
research Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing
Controlling immune responses with biomaterials can reduce scarring and improve skin regeneration.
research Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma
Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.
research 496 Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways
Researchers found that certain miRNAs, which affect immune system regulation, are differently expressed in mice with a hair loss condition compared to healthy mice.
research Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions
Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.
research A humanized IL-2 fusion protein enhances T regulatory cells in vivo and restrains disease in a murine model of Alopecia Areata 4760
A humanized IL-2 fusion protein boosts T regulatory cells and helps control hair loss in Alopecia Areata.
research Role of the SOX family in cancer immune evasion: Emerging player and promising therapeutic opportunities
Targeting SOX proteins may improve cancer treatment by restoring immune function.
research Local heroes or villains: tissue-resident memory T cells in human health and disease
Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.
research Surface-induced mechano-regulation of macrophages: emerging strategies for immunotherapy
Mechanical surface cues can control macrophage behavior for better immunotherapy and tissue healing.
research Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways
Certain microRNAs may help treat alopecia areata by targeting immune pathways.
research Il-10 family members as novel responders to genotoxic stress
IL-19 and IL-24 help cells respond to DNA damage and could be targeted for cancer and age-related disease treatments.
research Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application
New methods to improve the healing abilities of mesenchymal stem cells for disease treatment are promising but need more research.
research Interrelation of immunity and tissue repair or regeneration
The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.
research Innate immunity and the regulation and mobilization of keratinocyte stem cells: are the old players playing a new game?
Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.
research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization
Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.
research Immunosuppressive therapy in autoimmune disease — A review
Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.
research Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16 melanoma
B cells can both help and hinder the body's defense against melanoma.
research Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
research Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study
Immune cells and cytokines significantly affect pathological scar development.
research Editors' Picks
New findings suggest targeting IL-23 could treat psoriasis, skin cells can adapt to new roles, direct conversion of skin cells to blood cells may aid cell therapy, removing certain tumor cells could boost cancer immunotherapy, and melanoma may have many tumorigenic cells, not just cancer stem cells.
research CAQ Corner: Basic concepts of transplant immunology
The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.
research Editors' Picks
Activin increases skin tumor formation, skin Tregs help hair growth, lymph-node removal doesn't improve melanoma survival, cells can revert to stem cells in wound healing, and skin bacteria produce peptides that may treat infections.
research Quiescent Tissue Stem Cells Evade Immune Surveillance
Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
research Sex Hormones and their Analogues in Neuroimmune Biology
Sex hormones influence immune responses and may help treat diseases.