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research Rapid Screening of Anticoagulation Compounds for Biological Target-Associated Adverse Effects Using a Deep-Learning Framework in the Management of Atrial Fibrillation

September 2025 in “Bioengineering”

The framework helps predict adverse effects of blood thinners, improving drug selection for atrial fibrillation.

research Abstract ED05-04: Presurgical models to effectively screen preventive agents

December 2010 in “Cancer Prevention Research”

Presurgical models can effectively and affordably screen cancer prevention agents.

research De Novo Design of Anti-Aging Peptides

October 2025

New peptides can delay aging and improve cell function.

research DiZyme: The Ultimate Resource for Nanozyme Multiple Catalytic Activity Prediction

1 citations , November 2023 in “Research Square (Research Square)”

DiZyme accurately predicts nanozyme activities to aid in discovering new applications.

research Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches

January 2025 in “PROTEOMICS”

Drug repositioning is a promising way to quickly develop new treatments, especially for rare diseases.

research Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.

20 citations , October 1995 in “PubMed”

research Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data

5 citations , January 2018 in “Interdisciplinary sciences: computational life sciences”

Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

research Disposition and metabolism of finasteride in dogs.

5 citations , January 1997 in “PubMed”

Physicochemical Characterization of Finasteride: PEG 6000 and Finasteride: Kollidon K25 Solid Dispersions, and Finasteride: Beta-Cyclodextrin Inclusion Complexes

research Physicochemical characterization of finasteride:PEG 6000 and finasteride:Kollidon K25 solid dispersions, and finasteride: β-cyclodextrin inclusion complexes

11 citations , December 2010 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry”

Finasteride's solubility and bioavailability improved by forming solid dispersions and inclusion complexes.

research Predictive Skin Permeation of Ethinylestradiol,α-Asarone,Finasteride and Risperidone

January 2009 in “The Chinese Journal of Modern Applied Pharmacy”

The Potts-Guy model best predicts skin permeability for the tested drugs.

research High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

2 citations , December 2013 in “Xenobiotica”

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

research Drug–Drug Coamorphous System of Tadalafil and Finasteride for Enhanced Pharmaceutical Performance

December 2025 in “Molecular Pharmaceutics”

Combining tadalafil and finasteride improves their solubility and effectiveness.

research Design, synthesis and anti-tumor evaluation of novel thiohydantoin congeners as androgen receptor antagonists with in vivo study.

May 2024 in “Journal of molecular structure”

A new compound, 3a, effectively fights prostate cancer better than finasteride.

research Development of 3-D Microbioreactor Systems for Cell-Based High Throughput Screening

1 citations , June 2012 in “OhioLink ETD Center (Ohio Library and Information Network)”

A new 3-D bioreactor system improves drug screening and reduces animal testing.

Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety

7 citations , August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

research Comparative GC-MS Based In vitro Assays of 5α-Reductase Activity Using Rat Liver S9 Fraction

8 citations , March 2012 in “Mass spectrometry letters”

The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.

Rapid Generation of Homogenous Tumor Spheroid Microtissues in a Scaffold-Free Platform for High-Throughput Screening of a Novel Combination Nanomedicine

research Rapid generation of homogenous tumor spheroid microtissues in a scaffold-free platform for high-throughput screening of a novel combination nanomedicine

18 citations , February 2023 in “PLoS ONE”

A new triple drug system using nanoparticles effectively targets breast tumors in 3D models.

research Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats

January 2023 in “Cutaneous and Ocular Toxicology”

research Intradermal and follicular delivery of adapalene liposomes

27 citations , September 2015 in “Drug development and industrial pharmacy”

Liposomal adapalene improves delivery to hair follicles and reduces side effects for acne treatment.

research A Full Factorial Design to Optimize Aminexil Nano Lipid Formulation to Improve Skin Permeation and Efficacy Against Alopecia

12 citations , January 2023 in “AAPS PharmSciTech”

research 576 INTASYL PH-762: Intratumoral immunotherapy targeting PD-1

July 2024 in “Journal of Investigative Dermatology”

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

research Enhancement of Dermal Delivery of Finasteride Using MicroemulsionSystems

18 citations , October 2019 in “Advanced Pharmaceutical Bulletin”

Microemulsions can improve skin delivery of finasteride.

Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model

research Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model

15 citations , January 2024 in “The AAPS Journal”

50-mg ritlecitinib capsules are bioequivalent to 100-mg capsules.

research DNN-DTIs: improved drug-target interactions prediction using XGBoost feature selection and deep neural network

3 citations , August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The DNN-DTIs method accurately predicts drug-target interactions and is useful for drug repositioning.

research A novel derivative of doxorubicin, AD198, inhibits canine transitional cell carcinoma and osteosarcoma cells in vitro

12 citations , September 2015 in “Drug Design Development and Therapy”

AD198 is more effective than doxorubicin in stopping certain dog cancer cells.

research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System

16 citations , April 2000 in “Journal of Investigative Dermatology”

The AVET system effectively delivers genes to human keratinocytes and may help treat skin diseases.

Peer Review of Computational Drug Repositioning Based on Side-Effects Mined from Social Media

research Peer Review #3 of "Computational drug repositioning based on side-effects mined from social media (v0.3)"

February 2016

Reviewers criticized the study's methods and suggested focusing on drug mechanisms instead of repositioning due to social media data quality concerns.

research Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate

13 citations , January 1997 in “Biochemical Pharmacology”

Human liver enzyme DHEA ST helps process minoxidil.

research 708 SIG-1451: A topical anti-inflammatory new chemical entity for atopic dermatitis (AD)

April 2017 in “Journal of Investigative Dermatology”

SIG-1451 could be a promising new treatment for atopic dermatitis.

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