January 2012 in “Methods in pharmacology and toxicology” TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
290 citations
,
December 2017 in “Journal of The American Academy of Dermatology” Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
188 citations
,
March 2018 in “Frontiers in Immunology” Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.
155 citations
,
May 2016 in “Nature communications” Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.
134 citations
,
January 2019 in “American journal of clinical dermatology” Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.
131 citations
,
August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
124 citations
,
June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
124 citations
,
December 2016 in “Pharmaceuticals” TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
108 citations
,
December 2003 in “Lasers in surgery and medicine” ICG-enhanced NIR laser therapy may be a promising acne treatment with improvement and no side effects.
98 citations
,
November 2014 in “PLoS ONE” Hyaluronidase speeds up wound healing and reduces inflammation.
93 citations
,
April 2012 in “International Journal of Cosmetic Science” Improving skin barrier and using antifungal treatments can help manage dandruff.
78 citations
,
February 2011 in “Canadian Medical Association Journal” Acne treatment varies, with topical and systemic therapies effective, and more research needed on treatment order and long-term effects.
78 citations
,
April 1994 in “Archives of dermatology” The study found that Keratosis Pilaris Atrophicans is a genetic skin condition that starts in childhood, involves inflammation and scarring, and current treatments are only somewhat effective.
65 citations
,
May 2017 in “Advances in wound care” Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.
49 citations
,
August 2007 in “Dermatologic surgery” New treatments for acne scars are safer and more effective because we understand the causes better.
47 citations
,
December 2019 in “Frontiers in immunology” A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
43 citations
,
February 2019 in “International immunology” Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.
39 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.
30 citations
,
April 2007 in “Dermatologic Clinics” The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.
26 citations
,
December 2020 in “Nature metabolism” Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.
24 citations
,
January 2012 in “Journal of Cellular Biochemistry” C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.
21 citations
,
July 2020 in “Stem Cell Research & Therapy” Fat stem cells from diabetic mice can still help heal wounds.
20 citations
,
March 2017 in “Journal of cutaneous pathology” Shrinking of oil glands in the skin is a key sign of hair loss linked to TNF inhibitor drugs and may improve if the treatment is stopped.
18 citations
,
July 2008 in “Current Oncology Reports” EGFR cancer drugs often cause a rash, which can lead to distress and isolation, but may also improve outcomes for some cancer patients. Current treatments for the rash are limited, but a compound called menadione shows promise.
14 citations
,
January 2021 in “Scientific Reports” Using micro skin tissue columns improves skin wound healing and reduces scarring.
13 citations
,
January 2020 in “Scientific Reports” The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.
11 citations
,
February 2020 in “Dermatology and therapy” Low-Level Light Therapy significantly reduced inflammation and promoted hair regrowth in patients with Lichen planopilaris.
9 citations
,
July 2022 in “British Journal of Pharmacology” Blocking the mineralocorticoid receptor improves wound healing by reducing inflammation and promoting blood vessel growth.
9 citations
,
April 2021 in “Evidence-based complementary and alternative medicine” Guilu Erxian Glue may help reduce chemotherapy side effects like weight loss and heart stress.
8 citations
,
November 2024 in “EMBO Molecular Medicine” Targeting JAK-STAT1 can reduce inflammation and promote hair growth in conditions linked to EGFR deficiency.