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GlossaryInsulin-like Growth Factor

protein promoting cell growth and development, similar to insulin

Insulin-like Growth Factor (IGF) refers to a group of proteins with a structure similar to insulin that play a crucial role in growth and development, particularly during childhood. IGF is involved in cell growth, differentiation, and survival, and it is primarily produced in the liver in response to growth hormone stimulation. It has significant implications in various biological processes, including muscle growth, bone development, and even hair follicle health.

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Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro

60 citations , May 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig.

11 citations , January 1992 in “PubMed”

TGF-beta 1 and IGF-II mRNA have specific patterns in pig subcutaneous tissue, affecting fat and muscle development.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation

13 citations , October 2013 in “The Journal of Dermatology”

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model

research Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model

4 citations , April 2012 in “Asian-australasian Journal of Animal Sciences”

Red deer antler extract may help hair grow faster by increasing a growth protein.

research Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

29 citations , January 2016 in “Disease Markers”

Survivin and IGF-I may play a role in acne and scarring.

research Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice

29 citations , March 2011 in “The Journal of Nutritional Biochemistry”

Eating isoflavone can help mice grow hair by increasing a growth factor.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells

22 citations , February 2017 in “Clinical and Experimental Dermatology”

Icariin helps mouse hair grow by boosting a growth factor in skin cells.

research Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential

September 2025 in “Current Issues in Molecular Biology”

IGF-1 can help regrow hair and may be a promising treatment for hair loss.

research Association of insulin-like growth factor 2 Apa1 A820G gene (rs680) polymorphism with polycystic ovarian syndrome

January 2016 in “International journal of reproduction, contraception, obstetrics and gynecology”

A certain gene variation is linked to a higher risk of polycystic ovarian syndrome in South Indian women.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

IGF-1 can boost hair growth by promoting cell growth and preventing cell death.

The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia

49 citations , August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

Effect of Topical Application of Raspberry Ketone on Dermal Production of Insulin-Like Growth Factor-I in Mice and on Hair Growth and Skin Elasticity in Humans

research Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

39 citations , March 2008 in “Growth hormone & IGF research”

Raspberry ketone may help grow hair and improve skin elasticity.

research Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae

32 citations , February 2024 in “Growth Hormone & IGF Research”

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

research Insulin-like growth factor-1: roles in androgenetic alopecia

27 citations , February 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

26 citations , June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.

research Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1

22 citations , January 2011 in “Indian Journal of Dermatology/Indian journal of dermatology”

Cow placenta extract may help hair grow by increasing a growth factor but is less effective than minoxidil.

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

10 citations , August 2018 in “Dermatologic Surgery”

Laser treatment improves hair density and increases growth factors in androgenetic alopecia.

Both Low Circulating Insulin-Like Growth Factor-1 and High-Density Lipoprotein Cholesterol Are Associated with Hair Loss in Middle-Aged Women

research Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women

6 citations , March 2016 in “British Journal of Dermatology”

Low IGF-1 and high HDL cholesterol levels are linked to more hair loss in middle-aged women.

research Topical tacrolimus suppresses the expression of vascular endothelial growth factor and insulin-like growth factor-1 in late anagen

6 citations , June 2009 in “Clinical and Experimental Dermatology”

Topical tacrolimus reduces certain growth factors in hair follicles.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

3 citations , June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.

research Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

June 2023 in “Medical records-international medical journal”

Decreased IGF-1R expression may contribute to sacrococcygeal pilonidal sinus development.

research Erythropoietin induces insulin-like growth factor-1 from three-dimensional culture of human dermal papilla cells

October 2012 in “Journal of Dermatological Science”

Erythropoietin can promote hair growth by increasing IGF-1 in hair cells.

research Role of insulin-like growth factor-1 receptor in female androgenetic alopecia

January 2020 in “Menoufia Medical Journal”

IGF-1R may play a role in female hair loss and could be a treatment target.

research Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris

200 citations , August 2009 in “Experimental dermatology”

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

93 citations , January 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

research Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes

8 citations , January 2019 in “Annals of Dermatology”

Bilobetin may help reduce acne by decreasing sebum production.