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GlossaryInsulin-like Growth Factor 1

hormone promoting cell growth and development, similar to insulin

Insulin-like Growth Factor 1 (IGF-1) is a hormone similar in structure to insulin that plays a crucial role in childhood growth and continues to have anabolic effects in adults. It is primarily produced in the liver and is stimulated by growth hormone (GH). IGF-1 is involved in cell growth, development, and repair, and has been studied for its potential effects on hair growth and the treatment of conditions like alopecia.

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research Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig.

11 citations , January 1992 in “PubMed”

TGF-beta 1 and IGF-II mRNA have specific patterns in pig subcutaneous tissue, affecting fat and muscle development.

research Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential

September 2025 in “Current Issues in Molecular Biology”

IGF-1 can help regrow hair and may be a promising treatment for hair loss.

research Study on Expression of Insulin-like Growth Factor-binding Protein-3and -5(IGFBP-3 and IGFBP-5)in the Skin of Inner Mongolia Cashmere Goat

January 2013 in “China Animal Husbandry & Veterinary Medicine”

IGFBP-5 likely plays a key role in goat hair growth.

research effects Of Low-level Laser Therapy (lllt) On Dermal Papilla Cell Proliferation And Insulin-like Growth Factor-1 (igf-1) Secretion From Balding Hair Follicles : #lb12

April 2014

research Self-assembling peptide inspired by insulin and type 1 insulin-like growth factor for the treatment of androgenetic alopecia

August 2025 in “Bioactive Materials”

Ac-GFFY-IGF peptide is a promising, safe, and effective treatment for hair loss, better than current options.

research Insulin-like growth factor-1: roles in androgenetic alopecia

27 citations , February 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

research Promotion of Insulin-Like Growth Factor-I Production by Sensory Neuron Stimulation; Molecular Mechanism(s) and Therapeutic Implications

23 citations , December 2008 in “Current medicinal chemistry”

Stimulating sensory neurons can increase IGF-I production, which may help treat various diseases and improve tissue health.

research Role of insulin, insulin‐like growth factor‐1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris

200 citations , August 2009 in “Experimental dermatology”

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

IGF-1 can boost hair growth by promoting cell growth and preventing cell death.

Skin Expression of Mammalian Target of Rapamycin and Forkhead Box Transcription Factor O1, and Serum Insulin-Like Growth Factor-1 in Patients with Acne Vulgaris and Their Relationship with Diet

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

93 citations , January 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The expression of insulin-like growth factor 1 in follicular dermal papillae correlates with therapeutic efficacy of finasteride in androgenetic alopecia

49 citations , August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

26 citations , June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.

research Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells

22 citations , February 2017 in “Clinical and Experimental Dermatology”

Icariin helps mouse hair grow by boosting a growth factor in skin cells.

research Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1

22 citations , January 2011 in “Indian Journal of Dermatology/Indian journal of dermatology”

Cow placenta extract may help hair grow by increasing a growth factor but is less effective than minoxidil.

Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model

research Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model

4 citations , April 2012 in “Asian-australasian Journal of Animal Sciences”

Red deer antler extract may help hair grow faster by increasing a growth protein.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

3 citations , June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.

The Association Between Low Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 With Hair Loss in Women: A Case-Control Study in Basrah, Iraq

research The Association between Low (or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case-Control Study in Basrah, Iraq

April 2026 in “European Journal of Medical and Health Research”

Women with hair loss had lower IGF-1 levels.

research Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

June 2023 in “Medical records-international medical journal”

Decreased IGF-1R expression may contribute to sacrococcygeal pilonidal sinus development.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

147 citations , April 1997 in “Oncogene”

Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

Effect of Topical Application of Raspberry Ketone on Dermal Production of Insulin-Like Growth Factor-I in Mice and on Hair Growth and Skin Elasticity in Humans

research Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans

39 citations , March 2008 in “Growth hormone & IGF research”

Raspberry ketone may help grow hair and improve skin elasticity.

research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-like Growth Factor 1

33 citations , February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology”

IGF-1 increases whisker growth in transgenic mice.

research Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae

32 citations , February 2024 in “Growth Hormone & IGF Research”

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

research Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I

29 citations , January 2016 in “Disease Markers”

Survivin and IGF-I may play a role in acne and scarring.

research Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice

29 citations , March 2011 in “The Journal of Nutritional Biochemistry”

Eating isoflavone can help mice grow hair by increasing a growth factor.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of insulin‐like growth factor‐I by cepharanthine from dermal papilla cells: A novel potential pathway for hair growth stimulation

13 citations , October 2013 in “The Journal of Dermatology”

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

research Efficacy of 1,550-nm Erbium-Glass Fractional Laser Treatment and Its Effect on the Expression of Insulin-Like Growth Factor 1 and Wnt/β-Catenin in Androgenetic Alopecia

10 citations , August 2018 in “Dermatologic Surgery”

Laser treatment improves hair density and increases growth factors in androgenetic alopecia.