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GlossaryInterleukin-1 Receptor Antagonist

naturally occurring protein that inhibits inflammatory molecule interleukin-1

Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS

55 citations , January 2002 in “Journal of liposome research”

New liposomal formulations may improve delivery of treatments to hair follicles, potentially helping with hair loss.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

research Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling?

19 citations , September 2008 in “Journal of Cellular Physiology”

Blocking EGFR can cause skin inflammation by disrupting IL-1 signaling.

research IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures.

30 citations , August 1993 in “PubMed”

IL-1 alpha stops hair follicle growth and hair production.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle

14 citations , February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

research Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor

4 citations , July 2020 in “Biochemical and Biophysical Research Communications”

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

research New treatments for rheumatoid arthritis

13 citations , January 1999 in “Postgraduate Medicine”

New drugs for rheumatoid arthritis show improvement but have side effects and are not a cure.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Recent approaches of antibody therapeutics in androgenetic alopecia

August 2024 in “Frontiers in Pharmacology”

Antibody treatments show promise for hair loss but need more research.

research Emerging Therapies for Acne Vulgaris

22 citations , March 2018 in “American Journal of Clinical Dermatology”

New acne treatments show promise as alternatives to traditional therapies.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations , January 2011 in “Annals of Dermatology”

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

9 citations , January 2018 in “Acta dermato-venereologica”

A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.

research Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone

December 2023 in “Frontiers in pharmacology”

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

research GPCRs as key regulators in wound healing

April 2026 in “Frontiers in Cell and Developmental Biology”

GPCRs are vital for wound healing by affecting cell growth and immune response.

research 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis

September 2017 in “Journal of Investigative Dermatology”

LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.

research Molecular biology of hair morphogenesis: Development and cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist

9 citations , April 2021 in “Expert opinion on pharmacotherapy”

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

research Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology

176 citations , January 2003 in “Journal of Investigative Dermatology”

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

65 citations , June 2020 in “Stem Cell Research & Therapy”

Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.

research Baiting Proteins with C₆₀

106 citations , April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

research The itchy scalp - scratching for an explanation

61 citations , October 2011 in “Experimental dermatology”

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

research The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice

2 citations , May 2019 in “International Journal of Molecular Sciences”

Tranexamic acid turns white hair brown in certain mice by affecting specific proteins.

Inflammation in Androgenetic Alopecia and Hair Loss: Linking Neurosciences, Endocrinology, and Dermatology

research Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology

1 citations , May 2012 in “Hair transplant forum international”

Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.

research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

Dermal factors are crucial in regulating melanin production in skin.