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GlossaryInterleukin-1 Receptor Antagonist

naturally occurring protein that inhibits inflammatory molecule interleukin-1

Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures.

30 citations , August 1993 in “PubMed”

IL-1 alpha stops hair follicle growth and hair production.

research Improvement of atopic dermatitis and alopecia universalis with dupilumab: a case report

3 citations , December 2021 in “Dermatology reports”

Dupilumab can improve both atopic dermatitis and alopecia universalis.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

research FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS

55 citations , January 2002 in “Journal of liposome research”

New liposomal formulations may improve delivery of treatments to hair follicles, potentially helping with hair loss.

research Emerging Therapies for Acne Vulgaris

22 citations , March 2018 in “American Journal of Clinical Dermatology”

New acne treatments show promise as alternatives to traditional therapies.

research Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers

3 citations , January 2011 in “Annals of Dermatology”

Blocking EGFR in skin cells doesn't majorly increase inflammation markers.

research Hair-cycle changes in two patients taking tocilizumab

6 citations , August 2013 in “Joint Bone Spine”

Tocilizumab treatment was associated with significant hair regrowth in one patient and temporary hair loss followed by regrowth in another.

research Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture

15 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Erlotinib causes skin inflammation through IL-1, which can be reduced by anakinra.

research New treatments for rheumatoid arthritis

13 citations , January 1999 in “Postgraduate Medicine”

New drugs for rheumatoid arthritis show improvement but have side effects and are not a cure.

research Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata

1 citations , July 2012 in “Nasza Dermatologia Online”

IL-1α levels are higher in alopecia areata patients, suggesting a role in the disease.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

research Dupilumab: Friend or Foe to Alopecia Areata?

March 2021 in “International Journal of Clinical Dermatology & Research”

Dupilumab can help regrow hair in alopecia areata but stopping it may cause hair loss again.

Cutaneous Manifestations in Biologically Treated Inflammatory Bowel Disease Patients: A Narrative Review

research Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review

15 citations , March 2021 in “Journal of clinical medicine”

Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.

research Neuroimmunoregulation of Androgens in the Adrenal Gland and the Skin

48 citations , January 2000 in “Hormone Research in Paediatrics”

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

research Ultraviolet B irradiation increases the expression of inflammatory cytokines in cultured sebocytes

20 citations , December 2013 in “Journal of Dermatology”

UV-B light increases inflammation-related substances in acne-related skin cells.

research Old Wine in New Bottles: Reviving Old Therapies for Alopecia Areata Using Rodent Models

17 citations , September 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Old treatments for other skin conditions showed promise for hair regrowth in mice with a hair loss condition.

Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

research Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils

16 citations , September 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.

research Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

11 citations , February 2016 in “Current Medicinal Chemistry”

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

research Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

86 citations , April 2016 in “Nature Communications”

Notch1 helps skin heal by attracting specific immune cells.

research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

78 citations , June 2021 in “Dermatology and Therapy”

Future acne treatments should aggressively target inflammation to prevent scarring.

Ovarian Leukocyte Distribution and Cytokine/Chemokine mRNA Expression in Follicular Fluid Cells in Women with Polycystic Ovary Syndrome

research Ovarian leukocyte distribution and cytokine/chemokine mRNA expression in follicular fluid cells in women with polycystic ovary syndrome

69 citations , September 2006 in “Human Reproduction”

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

65 citations , June 2020 in “Stem Cell Research & Therapy”

Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.

research Effect of Ficus carica leaf extract on the gene expression of selected factors in HaCaT cells

16 citations , April 2017 in “Journal of Cosmetic Dermatology”

Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.

research Photoprotective and immunoregulatory capacity of ginsenoside Rg1 in chronic ultraviolet B-irradiated BALB/c mouse skin

6 citations , July 2013 in “Experimental and Therapeutic Medicine”

Ginsenoside Rg1 protects mouse skin from UVB damage and helps control inflammation.

Cytostatics and Immunosuppressive Drugs: Toxicities and Management

research Cytostatics and immunosuppressive drugs

January 1989 in “Side effects of drugs annual”

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Alopecia Induced by Tumor Necrosis Factor-Alpha Antagonists: Description of 52 Cases and Disproportionality Analysis in a Nationwide Pharmacovigilance Database

research Alopecia induced by tumour necrosis factor-alpha antagonists: description of 52 cases and disproportionality analysis in a nationwide pharmacovigilance database

26 citations , March 2014 in “Rheumatology”

Some drugs used to treat inflammation may cause hair loss.

research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist

9 citations , April 2021 in “Expert opinion on pharmacotherapy”

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner

research The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner

May 2025 in “Experimental Dermatology”

Triphenylphosphine oxide can increase oil production and reduce inflammation in skin cells without affecting TRPM5.

Pinus Thunbergii Bark Extract Rich in Flavonoids Promotes Hair Growth in Dorsal Skin by Regulating Inflammatory Cytokines and Increasing Growth Factors in Mice

research Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice

5 citations , January 2022 in “Molecular Medicine Reports”

Pine bark extract helps mice grow hair by reducing inflammation and boosting growth factors.