759 citations
,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
277 citations
,
July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
184 citations
,
December 2018 in “Nature Communications” Researchers created human hair follicles using a new method that could help treat hair loss.
103 citations
,
November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
98 citations
,
July 2014 in “Trends in Molecular Medicine” Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.
67 citations
,
December 2009 in “Stem Cells” β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.
60 citations
,
July 2011 in “Stem Cells and Development” Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
59 citations
,
June 2023 in “Nature Aging” Blocking IL-17 signaling may reduce skin inflammation and delay aging.
51 citations
,
November 2013 in “Drug Discovery Today” Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.
30 citations
,
December 2019 in “PLoS ONE” The new delivery system improved raloxifene's skin absorption and effectiveness against cancer cells.
15 citations
,
July 2013 in “Cell Reports” Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.
10 citations
,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
6 citations
,
June 2012 in “Physiology” The document concludes that more research is needed to understand airway repair and to improve tissue engineering for lung treatments.
1 citations
,
January 2012 in “Elsevier eBooks” The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.
260 citations
,
December 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
113 citations
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June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
23 citations
,
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” NF-κB is crucial for different stages and types of hair growth in mice.
7 citations
,
July 2012 in “Regenerative Medicine” New treatments for diabetes, central nervous system repair, and cartilage injury were found, and a way to create functional hair follicles from stem cells was developed.
3 citations
,
August 2012 in “Nature Cell Biology” Certain proteins help nerve cells branch, and other findings relate to cancer, stem cell behavior, and cell division.
2 citations
,
March 2021 in “Molecular Immunology” Dermal macrophages might help regrow hair.
1 citations
,
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Fetal skin has unique immune cells different from adult skin.
August 2012 in “Nature Cell Biology” Hair grows when stem cell offspring in the follicle base proliferate, influenced by the dermal papilla.
299 citations
,
January 2018 in “Journal of Clinical Investigation” Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
50 citations
,
September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids” Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.
28 citations
,
September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
Ocu-miR-205 affects hair density in Rex rabbits by promoting cell changes and influencing hair follicle phases.
Ocu-miR-205 affects hair density in Rex rabbits by promoting cell changes and influencing hair follicle phases.
Ocu-miR-205 affects hair density in Rex rabbits by influencing cell processes and signaling pathways.
November 2018 in “Atlas of genetics and cytogenetics in oncology and haematology” WNT10B is linked to cancer development and affects survival and disease progression in various cancers.
October 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Mice treatments didn't grow hair, a patient treatment may affect immune response, and people with hair loss often feel anxious or depressed.