August 2019 in “Journal of Investigative Dermatology” The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.
8 citations
,
September 2024 in “BMC Genomics” circCFAP20DC helps goat ovarian cells grow, aiding follicle development.
52 citations
,
February 2012 in “PloS one” Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
29 citations
,
July 2003 in “Experimental Dermatology” The upper hair follicle is stable, while the lower part allows movement during hair growth.
2 citations
,
July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” Autophagy changes the protein makeup of hair.
48 citations
,
May 1991 in “The journal of investigative dermatology/Journal of investigative dermatology” Trichohyalin is also found in the outer layers of normal human skin.
44 citations
,
September 2019 in “The EMBO Journal” Lymphatic vessels are essential for hair follicle growth and skin regeneration.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers made a detailed map of gene activity for different parts of human hair follicles to help create targeted hair disorder treatments.
30 citations
,
February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Plet-1 protein helps hair follicle cells move and stick to tissues.
27 citations
,
January 2012 in “Current Topics in Microbiology and Immunology” Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.
56 citations
,
March 2015 in “Journal of Investigative Dermatology” Healthy mitochondria in skin cells are essential for proper hair growth and skin cell interaction in mice.
April 2026 in “Cytotherapy” This study explores the role of immune-driven activation of hair follicle stem cells (HFSCs) as a potential model for developing cell-based therapies for hair regeneration, particularly in conditions like alopecia areata. Using a murine model with controlled immune stimulation via diphenylcyclopropenone (DPCP), researchers identified that macrophage-mediated signaling is crucial for HFSC activation and hair regeneration. The study demonstrated that immune stimulation leads to synchronized anagen initiation, expansion of Lgr5+/Sox9+ HFSCs, and activation of the Wnt/β-catenin pathway. Macrophages were found to accumulate near HFSC niches, and their depletion significantly reduced HFSC proliferation, highlighting their essential role in immune–stem cell interactions. This model provides a valuable platform for testing new regenerative strategies and developing advanced cell-based therapies for alopecia and similar disorders.
161 citations
,
April 2006 in “Journal of Investigative Dermatology” Liposomes with certain properties can effectively deliver drugs deep into hair follicles.
Type XVII collagen may help prevent skin aging.
1 citations
,
January 1989 Four antibodies were developed to help study hair follicle cell differentiation.
Introducing the OTC gene improved symptoms in mice with OTC deficiency.
13 citations
,
March 2020 in “Genes” Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.
January 2025 in “Indian Journal of Dermatology” Frontal fibrosing alopecia is a challenging hair loss condition with no known cause or definitive treatment.
5 citations
,
April 2020 in “Journal of Mind and Medical Sciences” The new device improves surgical accuracy by using a special dye and camera to see inside tissues.
52 citations
,
June 1991 in “Journal of Virology” The hamster polyomavirus middle T antigen is linked to tumors in hamsters and associates with a specific tyrosine kinase.
December 2021 in “Molecular genetics and genomics” Cats with abnormal hair had DSG4 gene changes causing hair problems.
January 2013 in “International Journal of Trichology” A new mutation in the TRPS1 gene was found in a Ukrainian girl with Trichorhinophalangeal syndrome type I.
47 citations
,
January 2003 in “Pharmaceutical Research” 38 citations
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January 2014 in “Journal of Dermatological Science” Krtap11-1 is important for hair strength and structure.
January 2011 in “Journal of Human Genetics” A Japanese patient with a rare genetic disorder had a less severe case than others, suggesting other factors may affect symptoms.
61 citations
,
September 2008 in “Stem Cells” Most hair follicle stem cells do not protect their DNA by dividing it unevenly.
Activin A increases inner ear hair cell development, while follistatin decreases it.
November 2025 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin” Sporadic trichoblastic neoplasms generally don't recur or spread, with one case showing a specific genetic fusion.
K15 and Id3 are important in hair follicle regeneration, with K15 increasing in early stages and Id3 responding later.
32 citations
,
March 2009 in “AAPS PharmSciTech”