Search

everythinglearnresearchcommunity

for

Search:↓

Neurosteroids play a key role in controlling the brain-adrenal gland activity in pregnant sheep, both in normal and stressful situations.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Finasteride blocks progesterone's effect on absence seizures in rats.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Prostaglandin F2alpha and related compounds can increase hair growth and darken hair in mice.

Allopregnanolone affects fear responses differently in male and female rats, possibly explaining sex differences in anxiety disorders.

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

Human adrenals and gonads have a unique enzyme for steroid hormone production.

Early changes in brain chemicals affect how a drug reduces alcohol intake in rats.

Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.

The methods accurately measured brain androgens, showing most 5α-androstane-3α,17β-diol comes from outside the brain, while androsterone is both transported and made in the brain.

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

5α-reduced neurosteroids may help regulate glial cell differentiation.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.

3α, 17β-androstanediol-glucuronide is not a useful marker for androgen excess but may help monitor certain treatments.

Neurosteroids show promise for treating epilepsy and more research is needed.

A new, efficient method was developed to synthesize a specific compound and its derivatives.

A new, safer method to make finasteride from progesterone is effective for industrial use.

Hair levels of estradiol and progesterone are higher in premenopausal than postmenopausal women, but the difference isn't statistically significant, indicating the need for a better measurement method.

Certain chemical changes to cortisol and progesterone can increase or decrease their ability to inhibit hair growth.

New compounds may help treat prostate issues without affecting androgen receptors.