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Protein Kinase C Epsilon, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

research Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

10 citations , January 2013 in “Journal of skin cancer”

PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.

research Promoter Methylation Changes in KRT17: A Novel Epigenetic Marker for Wool Production in Angora Rabbit

2 citations , May 2022 in “International journal of molecular sciences”

Changes in KRT17 gene activity linked to wool production in Angora rabbits.

CPK1 Activates CNGCs Through Phosphorylation for Calcium Signaling to Promote Root Hair Growth in Arabidopsis

research CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis

January 2025 in “Nature Communications”

CPK1 helps root hair growth in Arabidopsis by activating channels for calcium signaling.

research Keratins and disease at a glance

87 citations , September 2012 in “Journal of Cell Science”

Keratins are crucial for tissue strength, and mutations in keratin genes can lead to various diseases, highlighting the need for targeted therapies.

research An Ultra-high Sulfur Keratin Gene is Expressed Specifically During Hair Growth

38 citations , February 1989 in “Journal of Investigative Dermatology”

research The organization of the keratin I and II gene clusters in placental mammals and marsupials show a striking similarity

18 citations , November 2005 in “European Journal of Cell Biology”

Keratin gene clusters in humans and marsupials are similarly organized.

research 1392 Activation of Id2 gene regulatory network ruling quiescence of hair follicle stem cells

April 2018 in “Journal of Investigative Dermatology”

Id2 gene helps keep hair follicle stem cells inactive.

research Genomic Characterization of the Human Type I Cuticular Hair Keratin hHa2 and Identification of an Adjacent Novel Type I Hair Keratin Gene hHa5

33 citations , October 1996 in “Journal of Investigative Dermatology”

research DYS459, DYS391, DYS388 and DYS19 genetic loci have high allelic frequency in patients with prostate cancer

August 2015 in “International Journal of Genetics and Molecular Biology”

Certain genetic markers may increase or decrease prostate cancer risk.

research The Phenotypic and Genotypic Spectra of Ichthyosis With Confetti Plus Novel Genetic Variation in the 3′ End ofKRT10

22 citations , September 2014 in “JAMA dermatology”

Ichthyosis with confetti is a genetic skin disorder with consistent ectodermal malformations and various KRT10 gene mutations.

research Differential Expression of Genes Encoding a Cysteine-Rich Keratin Family in the Hair Cuticle

35 citations , September 1994 in “Journal of Investigative Dermatology”

Identification of a Cyclosporine-Specific P450 Hydroxylase Gene Through Targeted Cytochrome P450 Complement Disruption in Sebekia Benihana

research Identification of a Cyclosporine-Specific P450 Hydroxylase Gene through Targeted Cytochrome P450 Complement (CYPome) Disruption in Sebekia benihana

13 citations , January 2013 in “Applied and Environmental Microbiology”

A gene in Sebekia benihana, CYP-sb21, is needed for a specific reaction on the drug Cyclosporine A, which could be important for hair growth without affecting the immune system.

Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

research Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target

4 citations , September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

CD2 might be a new treatment target for patchy alopecia areata.

A Signature of Genes Including FGF11 Reveals Aberrant Fibroblast Activation and Immune Infiltration in Keloid Tissue

research A Signature of Genes Featuring FGF11 Revealed Aberrant Fibroblast Activation and Immune Infiltration Properties in Keloid Tissue

2 citations , August 2022 in “Emergency medicine international”

Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.

research Structure and hair follicle-specific expression of genes encoding the rat high sulfur protein B2 family

12 citations , February 1998 in “Gene”

The B2 genes are crucial for hair growth in rats.

research A New Heterozygous Variant of c.1225_1227delTTC (p.Phe409del) in Insulin Receptor Gene Associated with Severe Insulin Resistance and Hyperandrogenemia in an Adolescent Female with Type A Severe Insulin Resistance Syndrome

1 citations , November 2024 in “Diabetes Metabolic Syndrome and Obesity”

A specific gene variant is linked to severe insulin resistance and hormone imbalance in a teenage girl.

research A Ca ²⁺ /calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning

477 citations , March 2004 in “Proceedings of the National Academy of Sciences”

The DMI3 gene is essential for nodule development and symbiosis in certain plants.

research Gene expression profiling analysis reveals fur development in rex rabbits (Oryctolagus cuniculus)

23 citations , August 2017 in “Genome”

Gene expression affects fur development in rex rabbits.

research A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles

41 citations , January 2001 in “Journal of Investigative Dermatology”

research Molecular characterization of caprineKRTAP13-3in Liaoning cashmere goat in China

9 citations , September 2013 in “Journal of Applied Animal Research”

The genetic variation in the KAP13-3 gene may affect cashmere fiber traits in Liaoning goats.

research 1346 Functional roles of Krox20 (Egr2) in Epithelial Stem Cells

April 2023 in “Journal of Investigative Dermatology”

Krox20 (Egr2) is important for the function of epithelial stem cells.

research Genome Wide Differential Expression Profiles in Nevus Sebaceous Uncovered Low Expression of CDKN2AIP and Construction of a ceRNA Network

March 2022 in “Clinical Cosmetic and Investigational Dermatology”

CDKN2AIP gene is less active in nevus sebaceous, affecting related RNA networks.

research GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis

24 citations , December 2013 in “Archives of Dermatological Research”

research Human hair keratin-associated proteins: Sequence regularities and structural implications

52 citations , May 2006 in “Journal of Structural Biology”

Keratin-associated proteins help link filaments and affect keratin's strength.

research Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene

January 2022 in “Mammalian Genome”

The wavy coat in NCT mice is caused by multiple genes, including a mutation in the Prss53 gene.

Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/Beta-Catenin Signaling

research Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling

2 citations , December 2022 in “Pharmaceutics”

The enzyme pyruvate kinase M2 helps hair regrowth and could be a potential treatment for hair loss.

research Utilizing functional genomics approaches to characterize risk genes in alopecia areata

January 2020 in “Columbia Academic Commons (Columbia University)”

Certain genetic changes in the STX17 and KRT82 genes contribute to hair loss in alopecia areata.

research Trichocyte Keratin-Associated Proteins (KAPs)

17 citations , January 2018 in “Advances in experimental medicine and biology”

research A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population

21 citations , March 2015 in “Neurological Sciences”

A new genetic mutation linked to CARASIL syndrome and small artery disease was found in a Chinese family.

research Cloning of a putative keratin-associated protein cDNA expressed in various mouse tissues other than hair follicles

March 1998 in “Journal of Dermatological Science”

Keratin-associated proteins may have roles in various mouse tissues, not just hair.

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