829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
773 citations
,
August 2017 in “International Journal of Molecular Sciences” The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.
610 citations
,
April 2014 in “Nature Reviews Immunology” The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.
474 citations
,
January 2012 in “Chemistry & biology” Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
471 citations
,
October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
432 citations
,
April 2014 in “Nature communications” A mother's diet at conception can cause lasting genetic changes in her child.
416 citations
,
September 1997 in “Journal of Investigative Dermatology” People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.
405 citations
,
May 2007 in “Journal of The American Academy of Dermatology” Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.
402 citations
,
August 2011 in “Cancer research” Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
320 citations
,
December 2018 in “Frontiers in Immunology” Changing how mesenchymal stromal cells are grown can improve their healing abilities.
295 citations
,
March 2016 in “Life Sciences” Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.
271 citations
,
May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
271 citations
,
March 1999 in “Developmental biology” The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.
260 citations
,
December 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
249 citations
,
April 2002 in “The FASEB journal” Human skin can make serotonin and melatonin.
245 citations
,
January 1998 in “Genes & Development” Hoxc13 gene is essential for hair, nail, and papilla development.
232 citations
,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
196 citations
,
March 2016 in “Nature Communications” Genetic factors influence hair traits like shape, color, and greying in Latin Americans.
182 citations
,
June 2017 in “Biomaterials” Special fiber materials boost the healing properties of certain stem cells.
181 citations
,
January 2009 in “Nature Genetics” Certain mutations in a hair growth-related gene cause a type of genetic hair loss.
173 citations
,
January 2014 in “Nature Cell Biology” Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
165 citations
,
February 2014 in “Phytotherapy Research” Myrtle has various health benefits and potential for medicine development.
159 citations
,
July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
155 citations
,
March 2006 in “The American Journal of Medicine” Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.
150 citations
,
October 2010 in “The American Journal of Pathology” The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
149 citations
,
July 2017 in “PLoS Biology” Hair follicle patterns form through a mix of self-organization and signaling interactions.
149 citations
,
July 2002 in “Dermatologic clinics” Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.
147 citations
,
November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
147 citations
,
January 2014 in “American Journal of Clinical Dermatology” Laser device increases hair density, safe for treating hair loss in men and women.
146 citations
,
June 2012 in “PLoS ONE” Paneth cells help support stem cells and aid tissue regeneration after injury.