Search

for
Search:

GlossaryKeratin 5

protein providing structural support in skin and hair follicles

Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

Related Terms

Products matching "keratin 5"

Tracking 1 products like 254 Advanced Hair Revitalizing Formula from by companies like MV supplements . View product »

Sort by

Research

30 / 1000+ results

research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

215 citations , November 2000 in “Journal of Investigative Dermatology”

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

research Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

52 citations , October 2007 in “Molecular Therapy”

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

research Identification of somatic and germline mosaicism for a keratin 5 mutation in epidermolysis bullosa simplex in a family of which the proband was previously regarded as a sporadic case

26 citations , June 2004 in “Clinical Genetics”

The keratin 5 mutation in a family with epidermolysis bullosa simplex was due to mosaicism, not a new mutation.

research Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

15 citations , May 2014 in “Journal of Biological Chemistry”

A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.

research Expression of novel keratin associated protein 5 genes in the cuticle layer of human hair follicles

6 citations , April 2005 in “Journal of dermatological science”

The study found nine new hair protein genes in human hair follicles.

research A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice.

46 citations , May 1995 in “Proceedings of the National Academy of Sciences”

A specific gene region can control targeted and responsive gene expression in mice, useful for skin disorder treatments.

research Trichilemmoma.Features of keratin expression in CS-5 trichocyst system tumors.

1 citations , January 1995 in “Skin Cancer”

Immunohistochemistry helps accurately identify and differentiate malignant trichilemmoma.

research 583 Promoting hair growth and hair keratin production with a propolis extract

July 2024 in “Journal of Investigative Dermatology”

Propolis extract can promote hair growth and increase keratin production.

research Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter

47 citations , January 1998 in “Molecular Carcinogenesis”

ErbB2 signaling is crucial for skin cell growth and cancer development in mice.

Exploring The Effects Of Wetting And Free Fatty Acid Deposition On An Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1

research Exploring the Effects of Wetting and Free Fatty Acid Deposition on an Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1

1 citations , April 2023 in “Langmuir”

Damaged hair allows water to penetrate more easily, and fatty acids from shampoos can deposit on hair surfaces.

Exploring the Effects of Wetting and Free Fatty Acid Deposition on a Hair Fiber Surface Model Incorporating Keratin Associated Protein 5-1

research Exploring the effects of wetting and free fatty acid deposition on an atomistic hair fiber surface model incorporating Keratin Associated Protein 5-1

November 2022

Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.

research 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1)

5 citations , April 2019 in “Journal of Investigative Dermatology”

Oral JAK inhibitors improved alopecia areata by modulating immune responses and boosting hair growth.

research Molecular Cloning of 5′ Flanking Region of Ovine Keratin Associated Protein 6-1 Gene and Comparison of the Sequences

January 2007 in “Journal of Inner Mongolia University”

The research helps in creating genetically modified animals to study hair growth.

research Hair sheath keratins in follicular tumors. (5). Identification of hair sheath keratins in keratoacanthoma; Histopathological hair sheath structures in the tumor and their significance as differential histopathological criteria from squamous cell carcinoma.

January 1990 in “The Nishinihon Journal of Dermatology”

Follicular structures help differentiate keratoacanthoma from squamous cell carcinoma.

research One‐Step Tunable Human Hair Keratin Gradient Hydrogel with Antibacterial Activity for Tissue Engineering (Small 52/2025)

December 2025 in “Small”

A new hydrogel made from human hair keratin can help regenerate skin and fight bacteria.

research [An immunohistochemical study on the normal human anagen hair and hair follicle using anti-hair keratin monoclonal antibodies (HKN-5, HKN-6, HKN-7 and HKN-8)].

October 1985 in “PubMed”

research Keratin expression in basal cell carcinomas

128 citations , February 1992 in “British Journal of Dermatology”

Basal cell carcinomas likely originate from hair follicle cells or stem cells.

research The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties

46 citations , December 1998 in “Journal of Biological Chemistry”

Keratin 19 forms less stable and shorter filaments than keratin 14, giving unique traits to certain skin cells.

research Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex

40 citations , November 2021 in “International Journal of Molecular Sciences”

Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.

Histologic Morphology and Involucrin, Filaggrin, and Keratin Expression in Normal Canine Skin from Dogs of Different Breeds and Coat Types

research Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types

15 citations , January 2012 in “Journal of Veterinary Science”

Different dog breeds have varying skin thickness and protein expression in their skin.

research Keratin pattern in hyperkeratotic and ulcerated gastric pars oesophagea in pigs

13 citations , March 1997 in “Research in Veterinary Science/Research in veterinary science”

Epithelial proliferation and hyperkeratosis are linked to gastric ulcers in pigs.

research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy

10 citations , January 2010 in “International journal of trichology”

Keratin-associated proteins are part of the developing hair fiber cuticle.

research [Immunohistochemical study on the keratin expression in generating rat hair tissues using anti-hair keratin monoclonal antibodies].

July 1990 in “PubMed”

Hair germ cells differ from epidermal cells in keratin expression, and specific keratins form after hair differentiation.

research Table 5_Molecular mechanisms underlying cashmere quality differences between Jiangnan cashmere goats and Changthangi pashmina goats.docx

May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Differences in cashmere quality between goat breeds are linked to specific genes affecting hair follicle development.

research Abstract 5020: Characterization of epidermal stem cells in SKH1 hairless mice, a widely used mouse model to investigate ultraviolet radiation carcinogenesis.

April 2013 in “Cancer Research”

SKH1 hairless mice have identifiable epidermal stem cells with specific markers.

Interest of Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract in a New Anti-Hair Loss Serum to Stimulate Hair Growth and Prolong Anagen Phase

research 586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase

November 2022 in “Journal of Investigative Dermatology”

The extract of Silybum marianum, Manganese PCA, and Lespedeza capitata can boost hair growth and extend the growth phase when combined in a serum.

research 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

Skin Organoids Derived From NCSTN Mutated Patient-Induced Pluripotent Stem Cells Recapitulate Hidradenitis Suppurativa Pathogenic Hallmarks

research 545 Skin Organoids derived from NCSTN mutated patient-induced pluripotent stem cells recapitulate Hidradenitis Suppurativa pathogenic hallmarks

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin organoids with NCSTN mutation show changes in hair follicle development and higher inflammation, key features of Hidradenitis Suppurativa.

research 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

CTCF protein is essential for skin and hair follicle development in mice.