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GlossaryKeratin 85

protein crucial for hair structure and strength

Keratin 85, also known as KRT85, is a type of protein found in hair follicles. It plays a crucial role in the structure and strength of hair, contributing to its resilience and elasticity. Mutations in the KRT85 gene can lead to hair disorders, such as monilethrix, which is characterized by beaded or fragile hair.

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research Dynamics of Merkel Cell Patterns in Developing Hair Follicles in the Dorsal Skin of Mice, Demonstrated by a Monoclonal Antibody to Mouse Keratin 8

64 citations , January 1995 in “Cells Tissues Organs”

Merkel cells develop independently of nerves and are linked to specific hair follicles in mice.

research Mutations in the Keratin 85 (KRT85/hHb5) Gene Underlie Pure Hair and Nail Ectodermal Dysplasia

42 citations , October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the KRT85 gene cause hair and nail problems.

research Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage

38 citations , November 1991 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin”

Keratins 8 and 14 can help identify and diagnose benign skin tumors.

research Structural behavior of keratin-associated protein 8.1 in human hair as revealed by a monoclonal antibody

3 citations , August 2018 in “Journal of Structural Biology”

KAP8.1 protein is crucial for hair structure and interacts with keratin 85.

Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

research Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

November 2023 in “Advanced Science”

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene on Fiber Traits in Inner Mongolia Cashmere Goats

research Effect of the Polymorphisms of Keratin Associated Protein 8.2 Gene on Fibre Traits in Inner Mongolia Cashmere Goats

20 citations , May 2007 in “Asian-Australasian Journal of Animal Sciences”

KAP8.2 gene variations affect cashmere quality in goats.

research Study on kerantin association protein 8.1 gene expression of Liaoning cashere goats in skin and hair follicle

January 2014 in “China Feed”

Higher expression of the keratin-associated protein 8.1 gene in Liaoning cashmere goats is linked to finer cashmere fibers.

research Study on Differential Expression of Keratin Associated Protein 8-1 Gene of Different Varieties of Ovis aries in Skin and Hair Follicle

January 2014 in “China Animal Husbandry & Veterinary Medicine”

The KAP8-1 gene affects skin, hair follicle development, and wool quality in different sheep varieties.

research Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate

12 citations , January 1987 in “Carcinogenesis”

TCDD changes skin cell growth and keratin production in mice.

research The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes

35 citations , April 2008 in “Journal of Biological Chemistry”

Hirosaki hairless rats lack hair due to missing DNA with key keratin genes.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice

49 citations , August 2004 in “The FASEB Journal”

Mice with human skin protein K8 had more skin problems and cancer.

research Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair (vol 8, pg 241, 2008)

January 2009

research [An immunohistochemical study on the normal human anagen hair and hair follicle using anti-hair keratin monoclonal antibodies (HKN-5, HKN-6, HKN-7 and HKN-8)].

October 1985 in “PubMed”

research Keratin expression in basal cell carcinomas

128 citations , February 1992 in “British Journal of Dermatology”

Basal cell carcinomas likely originate from hair follicle cells or stem cells.

research Keratins and skin disease

69 citations , January 2015 in “Cell & tissue research/Cell and tissue research”

Keratin mutations cause skin diseases and could lead to new treatments.

research Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

15 citations , May 2014 in “Journal of Biological Chemistry”

A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.

research Characterization of the Human Hair Shaft Cuticle–Specific Keratin-Associated Protein 10 Family

11 citations , May 2013 in “Journal of Investigative Dermatology”

KRTAP10 proteins help form the hair shaft's tough outer layer by interacting with specific hair keratins.

iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

research iTRAQ-based quantitative proteomics revealing the therapeutic mechanism of a medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia by targeting keratins and TGF-β/Smad3 pathway

June 2024 in “Heliyon”

YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

research 583 Promoting hair growth and hair keratin production with a propolis extract

July 2024 in “Journal of Investigative Dermatology”

Propolis extract can promote hair growth and increase keratin production.

research Polymorphisms in the Human High Sulfur Hair Keratin-associated Protein 1, KAP1, Gene Family

48 citations , November 2002 in “Journal of biological chemistry/The Journal of biological chemistry”

Genetic variations in hair keratin proteins exist but don't significantly affect hair structure.

research Monilethrix in monozygotic twins with very rare mutation in KRT 86 gene

6 citations , March 2017 in “Journal of the European Academy of Dermatology and Venereology”

Identical twins with a rare KRT 86 gene mutation both have the hair disorder monilethrix.

research 895 Isoproterenol directs human hair follicle-associated pluripotent (hHAP) stem cells to differentiate to cardiac muscle cells

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human hair follicles can be used to create heart muscle cells.

research 840 Early and late matrix progenitors form the terminally differentiated cell layers of the hair follicle

April 2017 in “Journal of Investigative Dermatology”

Early and late matrix progenitors in hair follicles create different cell layers, with early ones forming the companion layer and later ones forming the inner root sheath and hair shaft.

research 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision

April 2017 in “Journal of Investigative Dermatology”

Sweat glands and hair follicles are determined by opposing signals, with BMPs promoting sweat glands and blocking BMPs leading to hair follicles.

research 837 From genotoxic stresses to skin damage: Distinct, novel mechanisms of skin and hair damage in chemo/radiation therapy

April 2017 in “Journal of Investigative Dermatology”

Chemotherapy and radiation therapy cause skin and hair damage by altering gene expression and signaling pathways.

Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Fate Maintenance, and Suppresses Inflammatory Responses in the Skin Epithelium

research 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium

April 2017 in “Journal of Investigative Dermatology”

The protein CTCF is essential for skin development, maintaining hair follicles, and preventing inflammation.

research Nestin expression in hair follicle sheath progenitor cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

Nestin is found in hair follicle progenitor cells, linking them to neural stem cells.

research EctopicAtoh1expression drives Merkel cell production in embryonic, postnatal and adult epidermis

41 citations , January 2015 in “Development”

Atoh1 expression can create new Merkel cells in the skin.

research Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology

33 citations , February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.