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research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) Represent the Type I Inner Root Sheath Keratins of the Human Hair Follicle

93 citations , July 2006 in “Journal of Investigative Dermatology”

K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.

research Ultrastructural localization of hair keratins, high sulfur keratin-associated proteins and sulfhydryl oxidase in the human hair

9 citations , February 2016 in “Anatomical Science International”

Hair proteins change location and structure as hair cells mature.

research Human keratin hydrogels support fibroblast attachment and proliferation in vitro

143 citations , January 2012 in “Cell and Tissue Research”

research Increased rate of hair keratin gene loss in the cetacean lineage

42 citations , January 2014 in “BMC Genomics”

Cetaceans lost hair genes to adapt to water.

research The molecular basis of human keratin disorders

79 citations , February 2009 in “Human Genetics”

research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

8 citations , June 2001 in “Journal of Biological Chemistry”

A truncated protein linked to breast cancer may change cell adhesion.

research Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix

175 citations , August 1997 in “Nature Genetics”

research Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair

115 citations , November 2008 in “Proceedings of the National Academy of Sciences”

Reptiles have genes similar to hair proteins, suggesting hair's genetic origins predate mammals.

research Identification and sequence analysis of the keratin-associated protein 24‐1 (KAP24-1) gene homologue in sheep

51 citations , September 2012 in “Gene”

The research identified a gene in sheep important for wool quality, which could help improve wool traits.

research Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82

9 citations , February 2022 in “Nature communications”

Rare changes in the KRT82 gene are linked to a higher risk of Alopecia Areata.

Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules

research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules

7 citations , July 2019 in “International Journal of Molecular Sciences”

PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.

research Ovine KRTAP36-2: A New Keratin-Associated Protein Gene Related to Variation in Wool Yield

November 2023 in “Genes”

The KRTAP36-2 gene in sheep affects wool yield.

research An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15

15 citations , January 1991 in “Mammalian Genome”

research Investigating the role of keratin proteins and microbial associations in hereditary and pathogenic alopecia

October 2024 in “Archives of Dermatological Research”

research Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog

70 citations , February 2007 in “Journal of Investigative Dermatology”

K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.

research Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

32 citations , June 2013 in “Journal of Investigative Dermatology”

Mice without certain skin proteins had abnormal skin and hair development.

research Structure and biochemistry of mammalian hard keratin

252 citations , January 1991 in “Electron Microscopy Reviews”

research The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors

18 citations , November 2005 in “Archives of Dermatological Research”

research The Proteins of Hair and Other Hard α-Keratins

85 citations , January 1990

research Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins

11 citations , January 1997 in “Journal of Dermatological Science”

A new protein linked to hair strength was identified, aiding in understanding brittle hair conditions.

research Runx1 transcription factor is involved in the regulation of KAP5 gene expression in human hair follicles

6 citations , January 2006 in “Journal of dermatological science”

Runx1 helps control the KAP5 gene in human hair follicles.

Chemical Bonds and Hair Behavior: A Review

research Chemical bonds and hair behaviour—A review

May 2024 in “International Journal of Cosmetic Science”

Disulfide bonds are crucial for hair's strength, especially when wet.

research Three-dimensional architecture of macrofibrils in the human scalp hair cortex

55 citations , February 2014 in “Journal of Structural Biology”

Human hair has a complex, variable structure with a consistent matrix and double-twist pattern.

Poster Presentations SG11 KRT14 Pathogenic Or Likely Pathogenic Variants Beyond Epidermolysis Bullosa: Dermatopathia Pigmentosa Reticularis

research Poster presentationsSG11 KRT14 pathogenic or likely pathogenic variants beyond epidermolysis bullosa: dermatopathia pigmentosa reticularis

June 2024 in “British Journal of Dermatology”

KRT14 gene variants cause dermatopathia pigmentosa reticularis, affecting nails, teeth, and hair.

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