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Protein Kinase C Epsilon, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

research Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

10 citations , January 2013 in “Journal of skin cancer”

PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.

research The Proteins of Hair and Other Hard α-Keratins

85 citations , January 1990

research Potential mechanisms of exercise in maintaining skin homeostasis disrupted by protein deficiency (Review)

March 2024 in “World Academy of Sciences Journal”

Exercise helps maintain healthy skin by promoting regeneration and reducing inflammation.

research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

132 citations , February 2002 in “Journal of Biological Chemistry”

HOXC13 is crucial for regulating hair keratin genes in hair follicles.

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

research Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families

40 citations , December 2010 in “Human Genetics”

research Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein

51 citations , September 2012 in “Biomacromolecules”

Disulfide bonds make keratin in hair stronger and tougher.

research Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins

13 citations , January 2018 in “Advances in experimental medicine and biology”

research The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

14 citations , December 2016 in “PloS one”

Keratin 26 affects cashmere goat hair growth and is influenced by various treatments.

research MOESM1 of A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse

January 2017

research 476 Development of an intrinsic skin sensor for blood glucose level with CRISPR-mediated genome editing in epidermal stem cells

April 2017 in “Journal of Investigative Dermatology”

Researchers created a skin graft that senses blood glucose and could treat diabetes using CRISPR-edited stem cells.

research De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks

2 citations , February 2021 in “FEBS open bio”

Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

Using special RNA to target a mutant gene fixed hair problems in mice.

research The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves

309 citations , October 2007 in “Biomaterials”

Keratin from human hair helps nerves heal faster.

research 1325 Age-dependent loss of the stemness and antimicrobial defense function of dermal fibroblasts is mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Spatiotemporal Expression and Haplotypes Identification of KRT84 Gene and Their Association with Wool Traits in Gansu Alpine Fine-Wool Sheep

February 2024 in “Genes”

The KRT84 gene is linked to better wool quality in Gansu Alpine Fine-wool sheep.

research Evolution of hard proteins in the sauropsid integument in relation to the cornification of skin derivatives in amniotes

86 citations , April 2009 in “Journal of anatomy”

Hard skin features like scales, feathers, and hair evolved through specific protein changes in different animal groups.

research A Review of Keratin-Based Biomaterials for Biomedical Applications

517 citations , February 2010 in “Materials”

Keratin from hair and wool is used in medical materials for healing and drug delivery.

research Keratins of the Human Hair Follicle

276 citations , January 2005 in “International review of cytology”

More research is needed to understand how hair keratins work and their role in hair disorders.

research Learning from nudity: lessons from the nude phenotype

86 citations , October 2005 in “Experimental Dermatology”

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex

77 citations , April 2005 in “Journal of Investigative Dermatology”

Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.

research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2

49 citations , August 1999 in “Journal of Investigative Dermatology”

Overexpressing the MSX-2 gene in mice causes skin and hair growth issues.

research Genetic disorders of keratin: are scarring alopecias a sub-set?

14 citations , July 1994 in “Journal of Dermatological Science”

Keratin mutations may cause scarring alopecia by damaging hair structure.

research Molecular Genetics of Alopecias

9 citations , January 2015 in “Current problems in dermatology”

Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.

research Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages

July 2024 in “Gene”

IRS-specific genes in Tan sheep hair follicles peak at birth and may affect wool crimp.

research Faculty Opinions recommendation of Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.

May 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A mutation in the KRT74 gene causes woolly hair by affecting hair texture.

research Faculty Opinions recommendation of Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture.

May 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A mutation in the KRT74 gene causes woolly hair by affecting hair texture.

research Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: “The World of Hair 2004”

November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2004 hair research meeting presented new findings on hair cell differentiation, genetic factors in hair loss, hair pigmentation, and potential targeted therapies.

research Ectopic production of hair keratin constitutes Rushton’s hyaline bodies in association with hematogenous deposits

6 citations , April 2012 in “Journal of Oral Pathology and Medicine”

Rushton's hyaline bodies form from hair keratin and blood substances.

research Genetic Susceptibility to Alopecia

5 citations , February 2019 in “The New England Journal of Medicine”

Certain mutations in the PADI3 gene may increase the risk of developing a type of scarring hair loss common in women of African descent.

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