63 citations
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July 2006 in “British Journal of Dermatology” Psoriasis causes changes in certain keratins and shrinks sebaceous glands in the scalp.
53 citations
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September 2004 in “American journal of medical genetics. Part C, Seminars in medical genetics” Mutations in keratin genes cause cell fragility and various skin disorders.
33 citations
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October 2012 in “Journal of Morphology” Reptile skin hardens by layering beta-proteins on keratin.
5 citations
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December 1996 in “Biochemical and Biophysical Research Communications” Mouse hair keratins mHa1 and mHb4 can't form a strong network on their own in cells.
1 citations
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June 2014 in “[Thesis]. Manchester, UK: The University of Manchester; 2014.” Chemical modifications can alter hair's stability and flexibility, with hydrophobic interactions helping maintain structure in humid conditions.
Chemical treatments weaken hair's thermal stability and structure.
November 2001 in “PubMed” Perming, combing, and stretching damage hair by reducing keratin.
August 2001 in “The Journal of Cell Biology” A new keratin gene was found in mice, explaining hair growth.
Perming, combing, and stretching damage hair by reducing keratin levels.
50 citations
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April 2019 in “Journal of Biosciences” 272 citations
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September 2001 in “Journal of Biological Chemistry” Human hair keratins were cataloged, showing their roles in hair differentiation stages.
93 citations
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July 2006 in “Journal of Investigative Dermatology” K25, K27, and K28 are found in all inner root sheath layers of hair, while K26 is only in the cuticle.
80 citations
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June 2002 in “Molecular Biology of the Cell” Type II keratins are uniquely phosphorylated during stress and mitosis, affecting their structure and function.
70 citations
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February 2007 in “Journal of Investigative Dermatology” K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.
47 citations
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June 1994 in “Experimental Cell Research” mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
41 citations
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May 2012 in “Advanced Healthcare Materials” Human hair keratins improve cell adhesion and growth on culture surfaces.
36 citations
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July 2019 in “Journal of Materials Science Materials in Medicine” Human hair keratin helps repair nerve damage in rats.
33 citations
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March 1994 in “PubMed” High ODC and low K1 and K10 may indicate early skin tumors in mice.
26 citations
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May 2001 in “British Journal of Dermatology” Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.
13 citations
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January 2018 in “Advances in experimental medicine and biology” 2 citations
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January 1989 in “The Nishinihon Journal of Dermatology” Seborrheic keratosis likely originates from the upper regions of hair follicles.
July 2017 in “Cancer Research” Krt15+ cells in mice can resist radiation, regenerate tissue, and start tumors, suggesting new cancer treatment targets.
January 1990 in “The Nishinihon Journal of Dermatology” Follicular structures help differentiate keratoacanthoma from squamous cell carcinoma.
May 2010 in “Journal of Investigative Dermatology” 90 citations
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July 1993 in “Journal of Investigative Dermatology” 61 citations
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February 1997 in “Differentiation” Hair differentiation starts earlier than thought, involving multiple type-II keratins.
38 citations
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July 1993 in “Journal of Investigative Dermatology” 27 citations
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November 1991 in “Journal of Investigative Dermatology” 23 citations
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February 1993 in “Journal of Investigative Dermatology” 1 citations
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August 2020 in “CRC Press eBooks” Hair growth can be influenced by manipulating keratin and growth factor genes.