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MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.

The study concludes that certain domains in Clostridium histolyticum enzymes are structurally unique, bind calcium to become more stable, and play distinct roles in breaking down collagen, with potential applications in medicine and drug delivery.

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

Acanthosis nigricans in teenage girls with PCOS is a sign of obesity, not insulin resistance or glucose intolerance.

Topical treatments like AHAs, BHAs, and urea may help keratosis pilaris, but evidence is limited.

The research found different metabolism changes in PCOS patients and suggested new potential markers for diagnosing PCOS with or without insulin resistance.

One minoxidil-sensitive potassium channel exists in human hair follicles.

Shell ginger contains kavalactones that promote hair growth and have anti-cancer, anti-inflammatory, and anti-obesity effects.

New steroid compounds may help with hormonal therapy and have potential benefits for glucose disorders, but more research is needed.

Only one K16 gene on chromosome 17 makes a functional keratin protein.

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Potassium channel openers like minoxidil boost hair growth.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.

Certain gene variations in AKT2 are more common in women with PCOS and are linked to higher levels of specific hormones and symptoms.

RSPO1 could help create new diabetes treatments by increasing pancreatic β cells.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Mutations in the KRT85 gene cause hair and nail problems.

Different types of skin on mice have unique chemical profiles related to how they grow and react to stress.

Hair and follicle keratins differ in structure and expression, especially in cysteine content.

Cardiac risk markers help assess heart risk in males with type 2 diabetes and low DHT.

Only one of the two K16 genes on chromosome 17 makes a functional protein for keratin filaments.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

KATP channels may help reduce itching in liver disease.